3-t-butyldiphenylsiloxy-11β-(3-isopropoxypropyl)estra-1,3,5(10)-trien-17-one

Base Information

Chemical Name:3-t-butyldiphenylsiloxy-11β-(3-isopropoxypropyl)estra-1,3,5(10)-trien-17-one
CAS No.:1373112-28-7
Molecular Formula:C₄₀H₅₂O₃Si
Molecular Weight:608.937
Hs Code.:

Synonyms:3-t-butyldiphenylsiloxy-11β-(3-isopropoxypropyl)estra-1,3,5(10)-trien-17-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-t-butyldiphenylsiloxy-11β-(3-isopropoxypropyl)estra-1,3,5(10)-trien-17-one

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Technology Process of 3-t-butyldiphenylsiloxy-11β-(3-isopropoxypropyl)estra-1,3,5(10)-trien-17-one

There total 8 articles about 3-t-butyldiphenylsiloxy-11β-(3-isopropoxypropyl)estra-1,3,5(10)-trien-17-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1373112-27-6
3-t-butyldiphenylsilyloxy-11β-(3-isopropoxypropyl)estra-1,3,5(10)-trien-17β-ol

: 1373112-28-7
3-t-butyldiphenylsiloxy-11β-(3-isopropoxypropyl)estra-1,3,5(10)-trien-17-one

Guidance literature:: With sodium acetate; pyridinium chlorochromate; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1016/j.cclet.2014.01.015

Reference yield:

: 342898-65-1
11α-allyl-3,17β-dibenzyloxyestra-1,3,5(10)-triene-11β-ol

: 1373112-28-7
3-t-butyldiphenylsiloxy-11β-(3-isopropoxypropyl)estra-1,3,5(10)-trien-17-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylsilane; boron trifluoride diethyl etherate / 0 °C

2.1: lithium borohydride; benzo[1,3,2]dioxaborole / tetrahydrofuran

3.1: pyridine / 0 °C

4.1: potassium hydride; 18-crown-6 ether / toluene / 20 °C

4.2: 80 °C

5.1: 5%-palladium/activated carbon; hydrogen / ethyl acetate; ethanol / 20 °C

6.1: dmap; triethylamine / dichloromethane / 20 °C

7.1: pyridinium chlorochromate; sodium acetate / dichloromethane / 2 h / 20 °C

With pyridine; triethylsilane; dmap; lithium borohydride; 18-crown-6 ether; 5%-palladium/activated carbon; boron trifluoride diethyl etherate; hydrogen; sodium acetate; potassium hydride; triethylamine; pyridinium chlorochromate; benzo[1,3,2]dioxaborole; In tetrahydrofuran; ethanol; dichloromethane; ethyl acetate; toluene;
DOI:10.1016/j.cclet.2014.01.015

Reference yield:

: 89155-71-5
(8S,9S,13S,14S,17S)-3,17-bis(benzyloxy)-13-methyl-6,7,8,9,12,13,14,15,16,17-decahydro-11H-cyclopenta[a]phenanthren-11-one

: 1373112-28-7
3-t-butyldiphenylsiloxy-11β-(3-isopropoxypropyl)estra-1,3,5(10)-trien-17-one

Guidance literature:: Multi-step reaction with 8 steps

1.1: tetrahydrofuran

2.1: triethylsilane; boron trifluoride diethyl etherate / 0 °C

3.1: lithium borohydride; benzo[1,3,2]dioxaborole / tetrahydrofuran

4.1: pyridine / 0 °C

5.1: potassium hydride; 18-crown-6 ether / toluene / 20 °C

5.2: 80 °C

6.1: 5%-palladium/activated carbon; hydrogen / ethyl acetate; ethanol / 20 °C

7.1: dmap; triethylamine / dichloromethane / 20 °C

8.1: pyridinium chlorochromate; sodium acetate / dichloromethane / 2 h / 20 °C

With pyridine; triethylsilane; dmap; lithium borohydride; 18-crown-6 ether; 5%-palladium/activated carbon; boron trifluoride diethyl etherate; hydrogen; sodium acetate; potassium hydride; triethylamine; pyridinium chlorochromate; benzo[1,3,2]dioxaborole; In tetrahydrofuran; ethanol; dichloromethane; ethyl acetate; toluene;
DOI:10.1016/j.cclet.2014.01.015