3-t-butyldiphenylsilyloxy-11β-(3-isopropoxypropyl)estra-1,3,5(10)-trien-17β-ol

Base Information

Chemical Name:3-t-butyldiphenylsilyloxy-11β-(3-isopropoxypropyl)estra-1,3,5(10)-trien-17β-ol
CAS No.:1373112-27-6
Molecular Formula:C₄₀H₅₄O₃Si
Molecular Weight:610.952
Hs Code.:

Synonyms:3-t-butyldiphenylsilyloxy-11β-(3-isopropoxypropyl)estra-1,3,5(10)-trien-17β-ol

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Chemical Property of 3-t-butyldiphenylsilyloxy-11β-(3-isopropoxypropyl)estra-1,3,5(10)-trien-17β-ol

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Technology Process of 3-t-butyldiphenylsilyloxy-11β-(3-isopropoxypropyl)estra-1,3,5(10)-trien-17β-ol

There total 6 articles about 3-t-butyldiphenylsilyloxy-11β-(3-isopropoxypropyl)estra-1,3,5(10)-trien-17β-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 89155-71-5
(8S,9S,13S,14S,17S)-3,17-bis(benzyloxy)-13-methyl-6,7,8,9,12,13,14,15,16,17-decahydro-11H-cyclopenta[a]phenanthren-11-one

: 1373112-27-6
3-t-butyldiphenylsilyloxy-11β-(3-isopropoxypropyl)estra-1,3,5(10)-trien-17β-ol

Guidance literature:: Multi-step reaction with 7 steps

1.1: tetrahydrofuran

2.1: triethylsilane; boron trifluoride diethyl etherate / 0 °C

3.1: lithium borohydride; benzo[1,3,2]dioxaborole / tetrahydrofuran

4.1: pyridine / 0 °C

5.1: potassium hydride; 18-crown-6 ether / toluene / 20 °C

5.2: 80 °C

6.1: 5%-palladium/activated carbon; hydrogen / ethyl acetate; ethanol / 20 °C

7.1: dmap; triethylamine / dichloromethane / 20 °C

With pyridine; triethylsilane; dmap; lithium borohydride; 18-crown-6 ether; 5%-palladium/activated carbon; boron trifluoride diethyl etherate; hydrogen; potassium hydride; triethylamine; benzo[1,3,2]dioxaborole; In tetrahydrofuran; ethanol; dichloromethane; ethyl acetate; toluene;
DOI:10.1016/j.cclet.2014.01.015

Reference yield:

: 534572-62-8
11β-allyl-3,17β-dibenzyloxyestra-1,3,5(10)-triene

: 1373112-27-6
3-t-butyldiphenylsilyloxy-11β-(3-isopropoxypropyl)estra-1,3,5(10)-trien-17β-ol

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium borohydride; benzo[1,3,2]dioxaborole / tetrahydrofuran

2.1: pyridine / 0 °C

3.1: potassium hydride; 18-crown-6 ether / toluene / 20 °C

3.2: 80 °C

4.1: 5%-palladium/activated carbon; hydrogen / ethyl acetate; ethanol / 20 °C

5.1: dmap; triethylamine / dichloromethane / 20 °C

With pyridine; dmap; lithium borohydride; 18-crown-6 ether; 5%-palladium/activated carbon; hydrogen; potassium hydride; triethylamine; benzo[1,3,2]dioxaborole; In tetrahydrofuran; ethanol; dichloromethane; ethyl acetate; toluene;
DOI:10.1016/j.cclet.2014.01.015

Reference yield:

: 849241-75-4
3-(3,17β-dibenzyloxyestra-1,3,5(10)-trien-11β-yl)propyl toluenesulfonate

: 1373112-27-6
3-t-butyldiphenylsilyloxy-11β-(3-isopropoxypropyl)estra-1,3,5(10)-trien-17β-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hydride; 18-crown-6 ether / toluene / 20 °C

1.2: 80 °C

2.1: 5%-palladium/activated carbon; hydrogen / ethyl acetate; ethanol / 20 °C

3.1: dmap; triethylamine / dichloromethane / 20 °C

With dmap; 18-crown-6 ether; 5%-palladium/activated carbon; hydrogen; potassium hydride; triethylamine; In ethanol; dichloromethane; ethyl acetate; toluene;
DOI:10.1016/j.cclet.2014.01.015