N-[4-hydroxy-3-(3-methoxyphenyl)-2-thiazolidinylidene]phenylsulfonamide

Base Information

• Chemical Name: N-[4-hydroxy-3-(3-methoxyphenyl)-2-thiazolidinylidene]phenylsulfonamide
• CAS No.: 247031-66-9
• Molecular Formula: C₁₆H₁₆N₂O₄S₂
• Molecular Weight: 364.446
• Mol file: 247031-66-9.mol

Synonyms:N-[4-hydroxy-3-(3-methoxyphenyl)-2-thiazolidinylidene]phenylsulfonamide

Chemical Property of N-[4-hydroxy-3-(3-methoxyphenyl)-2-thiazolidinylidene]phenylsulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[4-hydroxy-3-(3-methoxyphenyl)-2-thiazolidinylidene]phenylsulfonamide

There total 4 articles about N-[4-hydroxy-3-(3-methoxyphenyl)-2-thiazolidinylidene]phenylsulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

2-chloroethanal (107-20-0) + N-[[(3-methoxyphenyl)amino]thioxomethyl]phenylsulfonamide (70318-86-4) → N-[4-hydroxy-3-(3-methoxyphenyl)-2-thiazolidinylidene]phenylsulfonamide (247031-66-9)

Guidance literature:

With potassium carbonate; In water; acetone; for 2.5h; Heating;

DOI:10.1016/S0223-5234(99)80082-8

Reference yield:

benzenesulfonamide (98-10-2) → N-[4-hydroxy-3-(3-methoxyphenyl)-2-thiazolidinylidene]phenylsulfonamide (247031-66-9)

Guidance literature:

Multi-step reaction with 4 steps

1: aq. NaOH / dimethylformamide

2: dimethylformamide / 2 h / 20 °C

3: 77 percent / tetrahydrofuran / 20 h / Heating

4: 64 percent / K₂CO₃ / acetone; H₂O / 2.5 h / Heating

With sodium hydroxide; potassium carbonate; In tetrahydrofuran; water; N,N-dimethyl-formamide; acetone; 1: Addition / 2: Methylation / 3: Substitution / 4: Cyclization;

DOI:10.1016/S0223-5234(99)80082-8

Reference yield:

N-Benzensulfonyldithiocarbamidsaeuremethylester (20902-00-5) → N-[4-hydroxy-3-(3-methoxyphenyl)-2-thiazolidinylidene]phenylsulfonamide (247031-66-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 77 percent / tetrahydrofuran / 20 h / Heating

2: 64 percent / K₂CO₃ / acetone; H₂O / 2.5 h / Heating

With potassium carbonate; In tetrahydrofuran; water; acetone; 1: Substitution / 2: Cyclization;

DOI:10.1016/S0223-5234(99)80082-8

upstream raw materials:

2-chloroethanal

N-[[(3-methoxyphenyl)amino]thioxomethyl]phenylsulfonamide

benzenesulfonamide

N-Benzensulfonyldithiocarbamidsaeuremethylester

Downstream raw materials:

N-[2,3-dihydro-3-(3-methoxyphenyl)-2-thiazolylidene]phenylsulfonamide

3-[2,3-dihydro-2-[(phenylsulfonyl)imino]thiazol-3-yl]phenoxyacetic acid ethyl ester

N-[2,3-dihydro-3-(3-hydroxyphenyl)-2-thiazolylidene]phenylsulfonamide