20902-00-5

Upstream product

• 98-10-2 benzenesulfonamide 
• 75-15-0 carbon disulfide 
• 74-88-4 methyl iodide 
• 95921-11-2 C₇H₅NO₂S₃^(2-)*2Na⁽¹⁺⁾ 

Downstream Products

• 87840-20-8 N-Benzenesulfonyliminodithiokohlensaeure-S-methyl-S'-phenacyldiester 
• 86379-81-9 N-[5-Phenyl-[1,3]oxathiol-(2E)-ylidene]-benzenesulfonamide 
• 86379-82-0 N-[5-(4-Nitro-phenyl)-[1,3]oxathiol-(2E)-ylidene]-benzenesulfonamide 
• 13068-67-2 N-Benzolsulfonyl-thiocarbamidsaeure-O-methylester 
• 1424-53-9 benzenesulfonyl isothiocyanate 
• 13068-33-2 N,N',N''-Tri-benzolsulfonyl-guanidin 
• 13068-68-3 benzenesulfonyl-thiourea 
• 13068-44-5 N-Benzolsulfonyl-thiocarbamidsaeure-O-isopropylester 
• 13068-48-9 4-Benzolsulfonyl-1,1-diphenyl-thiosemicarbazid 
• 70318-87-5 N-[[(4-methoxyphenyl)amino]thioxomethyl]phenylsulfonamide 
• 70318-86-4 N-[[(3-methoxyphenyl)amino]thioxomethyl]phenylsulfonamide 
• 13111-47-2 N-Benzolsulfonylimino-dithiokohlensaeure-methylester-benzylester 
• 247031-73-8 N-[2,3-dihydro-3-(4-methoxyphenyl)-2-thiazolylidene]phenylsulfonamide 
• 247031-69-2 N-[2,3-dihydro-3-(3-methoxyphenyl)-2-thiazolylidene]phenylsulfonamide 

Relevant academic research and scientific papers

α-carbonic anhydrases possess thioesterase activity

The α-carbonic anhydrases (CAs, EC 4.2.1.1) show catalytic versatility acting as esterases with carboxylic, sulfonic, and phosphate esters. Here we prove by kinetic, spectroscopic, and MS studies that they also possess thioesterase activity with a dithiocarbamate ester as a substrate (PhSO2NHCSSMe). Its CA-mediated hydrolysis leads to benzenesulfonamide, methyl mercaptan, and COS. The CA thioesterase activity may be useful for designing prodrug enzyme inhibitors, whereas some CA isoforms may use this activity for modulating physiologic/pathologic processes, which are possibly amenable to drug discovery of agents with multiple mechanisms of action.

Synthesis, structural characterization and thromboxane A2 receptor antagonistic activity of 3-substituted 2-[(arylsulfonyl)imino]-2,3- dihydrothiazolyl derivatives

A series of new 2-[(arylsulfonyl)imino]-2,3-dihydrothiazolyl derivatives substituted on the heterocyclic N by a phenoxyacetic moiety was prepared according to a Hantzsch's synthesis between N, N'-disubstituted thioureas and chloroacetaldehyde. The regiochemistry of the cyclocondensation reaction was established by high resolution NMR methods. Potential thromboxane A2/prostaglandin H2 (TxA2/PGH2) receptor antagonism was evaluated using human platelet aggregation assays and radioligand binding studies. The results showed that the affinity for the TxA2/PGH2 receptor was strongly dependent on the position of the oxyacetic acid side chain. On the basis of the X-ray crystal analysis of compound 9f, a molecular modelling was undertaken on compounds 3d, 3e, and 3f. Comparison with the 3D structure of sulotroban was discussed.