di-tert-butyl <3-fluoro-4-benzoyl>-L-glutamate

Base Information

• Chemical Name: di-tert-butyl <3-fluoro-4-benzoyl>-L-glutamate
• CAS No.: 157665-36-6
• Molecular Formula: C₂₄H₃₇FN₂O₇
• Molecular Weight: 484.565
• Mol file: 157665-36-6.mol

Synonyms:di-tert-butyl <3-fluoro-4-benzoyl>-L-glutamate

Chemical Property of di-tert-butyl <3-fluoro-4-benzoyl>-L-glutamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of di-tert-butyl <3-fluoro-4-benzoyl>-L-glutamate

There total 3 articles about di-tert-butyl <3-fluoro-4-benzoyl>-L-glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

oxirane (75-21-8,99932-75-9) + di-tert-butyl N-(3-fluoro-4-aminobenzoyl)-l-glutamate (85803-28-7) → di-tert-butyl <3-fluoro-4-benzoyl>-L-glutamate (157665-36-6)

Guidance literature:

With acetic acid; for 72h; Ambient temperature;

DOI:10.1021/jm00041a015

Reference yield:

L-glutamic acid di-tert-butyl ester hydrochloride (32677-01-3) → di-tert-butyl <3-fluoro-4-benzoyl>-L-glutamate (157665-36-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 97 percent / Et₃N / CH₂Cl₂

2: 99 percent / ammonium formate / 10percent Pd/C / methanol

3: 51 percent / HOAc / 72 h / Ambient temperature

With ammonium formate; acetic acid; triethylamine; palladium on activated charcoal; In methanol; dichloromethane;

DOI:10.1021/jm00041a015

Reference yield:

di-tert-butyl N-(3-fluoro-4-nitrobenzoyl)-l-glutamate (85803-26-5) → di-tert-butyl <3-fluoro-4-benzoyl>-L-glutamate (157665-36-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 99 percent / ammonium formate / 10percent Pd/C / methanol

2: 51 percent / HOAc / 72 h / Ambient temperature

With ammonium formate; acetic acid; palladium on activated charcoal; In methanol;

DOI:10.1021/jm00041a015

upstream raw materials:

oxirane

di-tert-butyl N-(3-fluoro-4-aminobenzoyl)-l-glutamate

L-glutamic acid di-tert-butyl ester hydrochloride

di-tert-butyl N-(3-fluoro-4-nitrobenzoyl)-l-glutamate

Downstream raw materials:

di-tert-butyl <3-fluoro-4-benzoyl>-L-glutamate

di-tert-butyl <3-fluoro-4-<(2-chloroethyl)<2-(mesyloxy)ethyl>amino>benzoyl>-L-glutamate

di-tert-butyl <3-fluoro-4-amino>benzoyl>-L-glutamate