N,N'-Bis(P-toluenesulfonyl)hydrazine

Base Information

• Chemical Name: N,N'-Bis(P-toluenesulfonyl)hydrazine
• CAS No.: 14062-05-6
• Molecular Formula: C14H16 N2 O4 S2
• Molecular Weight: 340.424
• Hs Code.: 2935009090
• European Community (EC) Number: 625-187-1
• NSC Number: 179371
• DSSTox Substance ID: DTXSID80306698
• Nikkaji Number: J937.888J
• Wikidata: Q72470233
• Mol file: 14062-05-6.mol

Synonyms:14062-05-6;N,N'-BIS(P-TOLUENESULFONYL)HYDRAZINE;1,2-Bis(p-tolylsulfonyl)hydrazine;4-Methyl-N'-tosylbenzenesulfonohydrazide;4-methyl-N'-(4-methylphenyl)sulfonylbenzenesulfonohydrazide;MFCD00025987;1,2-Ditosylhydrazine;NSC179371;n,n'-ditosylhydrazine;SCHEMBL7627224;DTXSID80306698;AKOS024335364;Benzenesulfonic acid, 4-methyl-, 2-[(4-methylphenyl)sulfonyl]hydrazide;N,N'-bis(p-toluenesulfonyl) hydrazine;NSC-179371;AS-10226;SY034857;N,N-BIS(P-TOLUENESULFONYL)HYDRAZINE;CS-0046840;FT-0696672;N,N'-Bis(p-toluenesulfonyl)hydrazine, 97%;A897794;J-007406;N,N inverted exclamation mark -Bis(p-toluenesulfonyl)hydrazine;4-Methyl-N'-(4-methylbenzene-1-sulfonyl)benzene-1-sulfonohydrazide;4-Methyl-N'-[(4-methylphenyl)sulfonyl]benzenesulfonohydrazide #;1,2-Bis(p-tolylsulfonyl)hydrazine, N,Nmu-Ditosylhydrazine, 4-Methylbenzenesulfonic acid 2-[(4-met

Chemical Property of N,N'-Bis(P-toluenesulfonyl)hydrazine

Chemical Property:

• Vapor Pressure: 1.96E-10mmHg at 25°C
• Melting Point: 220-224 °C
• Boiling Point: 507.9°Cat760mmHg
• PKA: 6.37±0.50(Predicted)
• Flash Point: 260.9°C
• PSA: 109.10000
• Density: 1.355g/cm³
• LogP: 4.41860
• Storage Temp.: 2-8°C
• XLogP3: 2.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 5
• Exact Mass: 340.05514934
• Heavy Atom Count: 22
• Complexity: 495

Purity/Quality:

99% ^*data from raw suppliers

N,N''-bis(p-Toluenesulfonyl)hydrazine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)S(=O)(=O)NNS(=O)(=O)C2=CC=C(C=C2)C

Technology Process of N,N'-Bis(P-toluenesulfonyl)hydrazine

There total 11 articles about N,N'-Bis(P-toluenesulfonyl)hydrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

toluene-4-sulfonic acid (104-15-4) → N,N'-ditosylhydrazine (14062-05-6)

Guidance literature:

With carbazic acid; In neat (no solvent); at 100 ℃; for 5h; Green chemistry;

Reference yield: 92.0%

p-toluenesulfonyl chloride (98-59-9) + toluene-4-sulfonic acid hydrazide (1576-35-8) → N,N'-ditosylhydrazine (14062-05-6)

Guidance literature:

With pyridine; In dichloromethane; for 3h;

DOI:10.3762/bjoc.9.157

Reference yield: 90.0%

1,3-diphenylpropanedione (120-46-7,61346-73-4) + toluene-4-sulfonic acid hydrazide (1576-35-8) → N,N'-ditosylhydrazine (14062-05-6)

Guidance literature:

In methanol; for 8h; Heating;

upstream raw materials:

p-toluenesulfonyl chloride

toluene-4-sulfonic acid hydrazide

1,3-diphenylpropanedione

acetylacetone

Downstream raw materials:

N-Benzyl-N,N'-ditosylhydrazine

N-Benzyl-N'-phenacyl-N,N'-ditosylhydrazine

(N,N'-Ditosylhydrazo)diacetic acid diethyl ester

N,N'-Diphenacyl-N,N'-ditosylhydrazine

Refernces

• 1、 Guo, Bogeng,Hou, Linxi,Lu, Zhen,Xiao, Longqiang,Zhao, Yulai. "One-step synthesis of cyclic polypyrazole and the self-assembly vesicles driven by hydrogen bond". . . Retrieved 2021.
• 2、 Chu, Jia-Hong,Xu, Xun-Hui,Kang, Shu-Ming,Liu, Na,Wu, Zong-Quan. "Fast Living Polymerization and Helix-Sense-Selective Polymerization of Diazoacetates Using Air-Stable Palladium(II) Catalysts". . p. 17773 - 17781. Retrieved 2018.
• 3、 Barrios-Rivera, Jonathan,Xu, Yingjian,Clarkson, Guy J.,Wills, Martin. "Asymmetric transfer hydrogenation of heterocycle-containing acetophenone derivatives using N-functionalised [(benzene)Ru(II)(TsDPEN)] complexes". supporting information. . Retrieved 2021/12/02.
• 4、 Paterna, Roberta,Padanha, Rita,Russo, Roberto,Frade, Raquel F.M.,Faustino, Hélio,Gois, Pedro M.P.. "Synthesis of 4-substituted-3-Hydroxyquinolin-2(1H)-ones with anticancer activity". supporting information. . Retrieved 2020/02/11.