5-(2-amino-3-ethyl-4-οxo-3,4-dihydroquinazolin-6-yl)-N-(2,4-difluorophenyl)-2-methoxypyridin-3-sulfonamide

Base Information

Chemical Name:5-(2-amino-3-ethyl-4-οxo-3,4-dihydroquinazolin-6-yl)-N-(2,4-difluorophenyl)-2-methoxypyridin-3-sulfonamide
CAS No.:1383988-87-1
Molecular Formula:C₂₂H₁₉F₂N₅O₄S
Molecular Weight:487.487
Hs Code.:

Synonyms:5-(2-amino-3-ethyl-4-οxo-3,4-dihydroquinazolin-6-yl)-N-(2,4-difluorophenyl)-2-methoxypyridin-3-sulfonamide

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Chemical Property of 5-(2-amino-3-ethyl-4-οxo-3,4-dihydroquinazolin-6-yl)-N-(2,4-difluorophenyl)-2-methoxypyridin-3-sulfonamide

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Technology Process of 5-(2-amino-3-ethyl-4-οxo-3,4-dihydroquinazolin-6-yl)-N-(2,4-difluorophenyl)-2-methoxypyridin-3-sulfonamide

There total 8 articles about 5-(2-amino-3-ethyl-4-οxo-3,4-dihydroquinazolin-6-yl)-N-(2,4-difluorophenyl)-2-methoxypyridin-3-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 1383992-65-1
N-(2,4-difluorophenyl)-2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-3-sulfonamide

: 2161-29-7
2-amino-6-bromo-3-ethylquinazolin-4(3H)-one

: 1383988-87-1
5-(2-amino-3-ethyl-4-οxo-3,4-dihydroquinazolin-6-yl)-N-(2,4-difluorophenyl)-2-methoxypyridin-3-sulfonamide

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; In 1,4-dioxane; water; at 100 ℃; for 1h; Sealed tube;
DOI:10.1021/jm400781h

Reference yield:

: 52727-57-8
5-bromo-2-aminobenzoic acid methyl ester

: 1383988-87-1
5-(2-amino-3-ethyl-4-οxo-3,4-dihydroquinazolin-6-yl)-N-(2,4-difluorophenyl)-2-methoxypyridin-3-sulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / 50 °C

2: tetrahydrofuran; isopropyl alcohol / 1 h / 85 °C / Sealed tube

3: potassium carbonate; hydrogenchloride / water; dimethyl sulfoxide / 1 h / 100 °C / Sealed tube

4: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 1 h / 100 °C / Sealed tube

With pyridine; hydrogenchloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; potassium carbonate; In tetrahydrofuran; 1,4-dioxane; water; dimethyl sulfoxide; isopropyl alcohol;
DOI:10.1021/jm400781h

Reference yield:

: 1383992-64-0
5-bromo-N-(2,4-difluorophenyl)-2-methoxypyridine-3-sulfonamide

: 1383988-87-1
5-(2-amino-3-ethyl-4-οxo-3,4-dihydroquinazolin-6-yl)-N-(2,4-difluorophenyl)-2-methoxypyridin-3-sulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 2 h / 95 °C / Inert atmosphere

2: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 1 h / 100 °C / Sealed tube

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; In 1,4-dioxane; water;
DOI:10.1021/jm400781h