N-(2,4-difluorophenyl)-2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-3-sulfonamide

Base Information

Chemical Name:N-(2,4-difluorophenyl)-2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-3-sulfonamide
CAS No.:1383992-65-1
Molecular Formula:C₁₈H₂₁BF₂N₂O₅S
Molecular Weight:426.249
Hs Code.:

Synonyms:N-(2,4-difluorophenyl)-2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-3-sulfonamide

Suppliers and Price of N-(2,4-difluorophenyl)-2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-3-sulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(2,4-difluorophenyl)-2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-3-sulfonamide

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of N-(2,4-difluorophenyl)-2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-3-sulfonamide

There total 4 articles about N-(2,4-difluorophenyl)-2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-3-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1383992-65-1
N-(2,4-difluorophenyl)-2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-3-sulfonamide

Guidance literature:

Reference yield: 60.0%

: 1383992-64-0
5-bromo-N-(2,4-difluorophenyl)-2-methoxypyridine-3-sulfonamide

: 73183-34-3
bis(pinacol)diborane

: 1383992-65-1
N-(2,4-difluorophenyl)-2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-3-sulfonamide

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; In 1,4-dioxane; at 95 ℃; for 2h; Inert atmosphere;
DOI:10.1021/jm400781h

Reference yield:

: 588729-99-1
3-amino-5-bromo-2-chloropyridine

: 1383992-65-1
N-(2,4-difluorophenyl)-2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-3-sulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: thionyl chloride; copper(l) chloride; sodium nitrate; hydrogenchloride / water / -5 - 3 °C / Cooling with acetone-dry ice

2.1: pyridine / dichloromethane / 20 °C

2.2: 4 h / 50 °C

3.1: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 2 h / 95 °C / Inert atmosphere

With pyridine; hydrogenchloride; sodium nitrate; thionyl chloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; copper(l) chloride; In 1,4-dioxane; dichloromethane; water;
DOI:10.1021/jm400781h