1,4-bis<<<(1,1-dimethylethyl)dimethylsilyl>oxy>methyl>-1-<7'-(phenylmethoxy)-1'-indanyl>-2-butyne

Base Information

Chemical Name:1,4-bis<<<(1,1-dimethylethyl)dimethylsilyl>oxy>methyl>-1-<7'-(phenylmethoxy)-1'-indanyl>-2-butyne
CAS No.:124887-33-8
Molecular Formula:C₃₂H₄₈O₃Si₂
Molecular Weight:536.902
Hs Code.:

Synonyms:1,4-bis<<<(1,1-dimethylethyl)dimethylsilyl>oxy>methyl>-1-<7'-(phenylmethoxy)-1'-indanyl>-2-butyne

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Chemical Property of 1,4-bis<<<(1,1-dimethylethyl)dimethylsilyl>oxy>methyl>-1-<7'-(phenylmethoxy)-1'-indanyl>-2-butyne

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Technology Process of 1,4-bis<<<(1,1-dimethylethyl)dimethylsilyl>oxy>methyl>-1-<7'-(phenylmethoxy)-1'-indanyl>-2-butyne

There total 6 articles about 1,4-bis<<<(1,1-dimethylethyl)dimethylsilyl>oxy>methyl>-1-<7'-(phenylmethoxy)-1'-indanyl>-2-butyne which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6968-35-0
7-hydroxy-indan-1-one

: 124887-33-8
1,4-bis<<<(1,1-dimethylethyl)dimethylsilyl>oxy>methyl>-1-<7'-(phenylmethoxy)-1'-indanyl>-2-butyne

Guidance literature:: Multi-step reaction with 5 steps

1: 94 percent / potassium carbonate, tetrabutylammonium iodide / dimethylformamide / 10 h / Ambient temperature

2: 1) potassium tert-butoxide / 1) dioxane, 0 deg C , then 0.8 h, RT 2) dioxane, 2 h , RT, then reflux 2h

3: 75 percent / p-toluenesulfonic acid / H₂O; dioxane / 16 h / Heating

4: 1) n-butyllithium / 1) THF, -78 deg C 2) THF, 0 deg C, 2 h

5: imidazole / dimethylformamide / 29 h / Ambient temperature

With 1H-imidazole; n-butyllithium; potassium tert-butylate; tetra-(n-butyl)ammonium iodide; potassium carbonate; toluene-4-sulfonic acid; In 1,4-dioxane; water; N,N-dimethyl-formamide;
DOI:10.1021/jo00293a043

Reference yield:

: 125494-84-0
7-(phenylmethoxy)indan-1-one

: 124887-33-8
1,4-bis<<<(1,1-dimethylethyl)dimethylsilyl>oxy>methyl>-1-<7'-(phenylmethoxy)-1'-indanyl>-2-butyne

Guidance literature:: Multi-step reaction with 4 steps

1: 1) potassium tert-butoxide / 1) dioxane, 0 deg C , then 0.8 h, RT 2) dioxane, 2 h , RT, then reflux 2h

2: 75 percent / p-toluenesulfonic acid / H₂O; dioxane / 16 h / Heating

3: 1) n-butyllithium / 1) THF, -78 deg C 2) THF, 0 deg C, 2 h

4: imidazole / dimethylformamide / 29 h / Ambient temperature

With 1H-imidazole; n-butyllithium; potassium tert-butylate; toluene-4-sulfonic acid; In 1,4-dioxane; water; N,N-dimethyl-formamide;
DOI:10.1021/jo00293a043

Reference yield:

: 125494-86-2
1-formyl-7-(phenylmethoxy)indane

: 124887-33-8
1,4-bis<<<(1,1-dimethylethyl)dimethylsilyl>oxy>methyl>-1-<7'-(phenylmethoxy)-1'-indanyl>-2-butyne

Guidance literature:: Multi-step reaction with 2 steps

1: 1) n-butyllithium / 1) THF, -78 deg C 2) THF, 0 deg C, 2 h

2: imidazole / dimethylformamide / 29 h / Ambient temperature

With 1H-imidazole; n-butyllithium; In N,N-dimethyl-formamide;
DOI:10.1021/jo00293a043