6-(3-{4-Bromo-2-[3-(4-methyl-piperazin-1-yl)-propionylamino]-phenylsulfanyl}-phenylcarbamoyl)-hexanoic acid methyl ester

Base Information

Chemical Name:6-(3-{4-Bromo-2-[3-(4-methyl-piperazin-1-yl)-propionylamino]-phenylsulfanyl}-phenylcarbamoyl)-hexanoic acid methyl ester
CAS No.:209608-45-7
Molecular Formula:C₂₈H₃₇BrN₄O₄S
Molecular Weight:605.596
Hs Code.:

Synonyms:6-(3-{4-Bromo-2-[3-(4-methyl-piperazin-1-yl)-propionylamino]-phenylsulfanyl}-phenylcarbamoyl)-hexanoic acid methyl ester

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Chemical Property of 6-(3-{4-Bromo-2-[3-(4-methyl-piperazin-1-yl)-propionylamino]-phenylsulfanyl}-phenylcarbamoyl)-hexanoic acid methyl ester

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Technology Process of 6-(3-{4-Bromo-2-[3-(4-methyl-piperazin-1-yl)-propionylamino]-phenylsulfanyl}-phenylcarbamoyl)-hexanoic acid methyl ester

There total 8 articles about 6-(3-{4-Bromo-2-[3-(4-methyl-piperazin-1-yl)-propionylamino]-phenylsulfanyl}-phenylcarbamoyl)-hexanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 20291-40-1
7-methoxy-7-oxoheptanoic acid

: 209608-45-7
6-(3-{4-Bromo-2-[3-(4-methyl-piperazin-1-yl)-propionylamino]-phenylsulfanyl}-phenylcarbamoyl)-hexanoic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / SOCl₂ / CH₂Cl₂ / 2 h / Heating

2: 83 percent / TEA / CH₂Cl₂ / 12 h / Ambient temperature

3: 100 percent / Fe, 12N HCl / aq. ethanol / 1 h / Heating

4: 1-ethylpiperidine / tetrahydrofuran / 3 h / 0 °C

5: tetrahydrofuran / 4 h / Heating

With 1-ethyl-piperidine; hydrogenchloride; thionyl chloride; TEA; iron; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1016/S0960-894X(98)00180-2

Reference yield:

: 35444-47-4
Methylpimeloyl chloride

: 209608-45-7
6-(3-{4-Bromo-2-[3-(4-methyl-piperazin-1-yl)-propionylamino]-phenylsulfanyl}-phenylcarbamoyl)-hexanoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 83 percent / TEA / CH₂Cl₂ / 12 h / Ambient temperature

2: 100 percent / Fe, 12N HCl / aq. ethanol / 1 h / Heating

3: 1-ethylpiperidine / tetrahydrofuran / 3 h / 0 °C

4: tetrahydrofuran / 4 h / Heating

With 1-ethyl-piperidine; hydrogenchloride; TEA; iron; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1016/S0960-894X(98)00180-2

Reference yield:

: 3460-18-2
1,4-dibromo-2-nitrobenzene

: 209608-45-7
6-(3-{4-Bromo-2-[3-(4-methyl-piperazin-1-yl)-propionylamino]-phenylsulfanyl}-phenylcarbamoyl)-hexanoic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 84 percent / AcONa / ethanol / 36 h / Heating

2: 83 percent / TEA / CH₂Cl₂ / 12 h / Ambient temperature

3: 100 percent / Fe, 12N HCl / aq. ethanol / 1 h / Heating

4: 1-ethylpiperidine / tetrahydrofuran / 3 h / 0 °C

5: tetrahydrofuran / 4 h / Heating

With 1-ethyl-piperidine; hydrogenchloride; TEA; sodium acetate; iron; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1016/S0960-894X(98)00180-2