6-(3-{4-Bromo-2-[3-(4-methyl-piperazin-1-yl)-propionylamino]-phenylsulfanyl}-phenylcarbamoyl)-hexanoic acid

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Chemical Name:6-(3-{4-Bromo-2-[3-(4-methyl-piperazin-1-yl)-propionylamino]-phenylsulfanyl}-phenylcarbamoyl)-hexanoic acid
CAS No.:209608-46-8
Molecular Formula:C₂₇H₃₅BrN₄O₄S
Molecular Weight:591.569
Hs Code.:

Synonyms:6-(3-{4-Bromo-2-[3-(4-methyl-piperazin-1-yl)-propionylamino]-phenylsulfanyl}-phenylcarbamoyl)-hexanoic acid

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Chemical Property of 6-(3-{4-Bromo-2-[3-(4-methyl-piperazin-1-yl)-propionylamino]-phenylsulfanyl}-phenylcarbamoyl)-hexanoic acid

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Technology Process of 6-(3-{4-Bromo-2-[3-(4-methyl-piperazin-1-yl)-propionylamino]-phenylsulfanyl}-phenylcarbamoyl)-hexanoic acid

There total 9 articles about 6-(3-{4-Bromo-2-[3-(4-methyl-piperazin-1-yl)-propionylamino]-phenylsulfanyl}-phenylcarbamoyl)-hexanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 209608-45-7
6-(3-{4-Bromo-2-[3-(4-methyl-piperazin-1-yl)-propionylamino]-phenylsulfanyl}-phenylcarbamoyl)-hexanoic acid methyl ester

: 209608-46-8
6-(3-{4-Bromo-2-[3-(4-methyl-piperazin-1-yl)-propionylamino]-phenylsulfanyl}-phenylcarbamoyl)-hexanoic acid

Guidance literature:: With sodium carbonate; In methanol; for 24h; Ambient temperature;
DOI:10.1016/S0960-894X(98)00180-2

Reference yield:

: 20291-40-1
7-methoxy-7-oxoheptanoic acid

: 209608-46-8
6-(3-{4-Bromo-2-[3-(4-methyl-piperazin-1-yl)-propionylamino]-phenylsulfanyl}-phenylcarbamoyl)-hexanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 100 percent / SOCl₂ / CH₂Cl₂ / 2 h / Heating

2: 83 percent / TEA / CH₂Cl₂ / 12 h / Ambient temperature

3: 100 percent / Fe, 12N HCl / aq. ethanol / 1 h / Heating

4: 1-ethylpiperidine / tetrahydrofuran / 3 h / 0 °C

5: tetrahydrofuran / 4 h / Heating

6: 100 percent / aq. Na₂CO₃ / methanol / 24 h / Ambient temperature

With 1-ethyl-piperidine; hydrogenchloride; thionyl chloride; TEA; iron; sodium carbonate; In tetrahydrofuran; methanol; ethanol; dichloromethane;
DOI:10.1016/S0960-894X(98)00180-2

Reference yield:

: 35444-47-4
Methylpimeloyl chloride

: 209608-46-8
6-(3-{4-Bromo-2-[3-(4-methyl-piperazin-1-yl)-propionylamino]-phenylsulfanyl}-phenylcarbamoyl)-hexanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 83 percent / TEA / CH₂Cl₂ / 12 h / Ambient temperature

2: 100 percent / Fe, 12N HCl / aq. ethanol / 1 h / Heating

3: 1-ethylpiperidine / tetrahydrofuran / 3 h / 0 °C

4: tetrahydrofuran / 4 h / Heating

5: 100 percent / aq. Na₂CO₃ / methanol / 24 h / Ambient temperature

With 1-ethyl-piperidine; hydrogenchloride; TEA; iron; sodium carbonate; In tetrahydrofuran; methanol; ethanol; dichloromethane;
DOI:10.1016/S0960-894X(98)00180-2