benzyl (3S)-3-(1-propyn-1-yl)-4-(5-(2,2,2-trifluoro-1-hydroxy-1-(hydroxymethyl)ethyl)-2-pyrimidinyl)-1-piperazinecarboxylate

Base Information

Chemical Name:benzyl (3S)-3-(1-propyn-1-yl)-4-(5-(2,2,2-trifluoro-1-hydroxy-1-(hydroxymethyl)ethyl)-2-pyrimidinyl)-1-piperazinecarboxylate
CAS No.:1450620-47-9
Molecular Formula:C₂₂H₂₃F₃N₄O₄
Molecular Weight:464.444
Hs Code.:

Synonyms:benzyl (3S)-3-(1-propyn-1-yl)-4-(5-(2,2,2-trifluoro-1-hydroxy-1-(hydroxymethyl)ethyl)-2-pyrimidinyl)-1-piperazinecarboxylate

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Chemical Property of benzyl (3S)-3-(1-propyn-1-yl)-4-(5-(2,2,2-trifluoro-1-hydroxy-1-(hydroxymethyl)ethyl)-2-pyrimidinyl)-1-piperazinecarboxylate

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Technology Process of benzyl (3S)-3-(1-propyn-1-yl)-4-(5-(2,2,2-trifluoro-1-hydroxy-1-(hydroxymethyl)ethyl)-2-pyrimidinyl)-1-piperazinecarboxylate

There total 11 articles about benzyl (3S)-3-(1-propyn-1-yl)-4-(5-(2,2,2-trifluoro-1-hydroxy-1-(hydroxymethyl)ethyl)-2-pyrimidinyl)-1-piperazinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1450620-45-7
benzyl (3S)-3-(1-propyn-1-yl)-4-(5-(1-(trifluoromethyl)ethenyl)-2-pyrimidinyl)-1-piperazinecarboxylate

: 1450620-47-9
benzyl (3S)-3-(1-propyn-1-yl)-4-(5-(2,2,2-trifluoro-1-hydroxy-1-(hydroxymethyl)ethyl)-2-pyrimidinyl)-1-piperazinecarboxylate

Guidance literature:: With potassium osmate dihydrate; 4-methylmorpholine N-oxide; In water; tert-butyl alcohol; at 20 ℃; for 72h;

Reference yield:

: 1450620-46-8
C₂₅H₃₁BN₄O₄

: 1450620-47-9
benzyl (3S)-3-(1-propyn-1-yl)-4-(5-(2,2,2-trifluoro-1-hydroxy-1-(hydroxymethyl)ethyl)-2-pyrimidinyl)-1-piperazinecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / tetrahydrofuran / Sealed tube; Inert atmosphere

1.2: 15 h / 60 °C / Cooling with ice

2.1: potassium osmate dihydrate; 4-methylmorpholine N-oxide / water; tert-butyl alcohol / 72 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium osmate dihydrate; sodium carbonate; 4-methylmorpholine N-oxide; In tetrahydrofuran; water; tert-butyl alcohol;

Reference yield:

: 1450620-44-6
benzyl (3S)-4-(5-bromo-2-pyrimidinyl)-3-(1-propyn-1-yl)-1-piperazinecarboxylate

: 1450620-47-9
benzyl (3S)-3-(1-propyn-1-yl)-4-(5-(2,2,2-trifluoro-1-hydroxy-1-(hydroxymethyl)ethyl)-2-pyrimidinyl)-1-piperazinecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / dimethyl sulfoxide / 24 h / 100 °C / Inert atmosphere

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / tetrahydrofuran / Sealed tube; Inert atmosphere

2.2: 15 h / 60 °C / Cooling with ice

3.1: potassium osmate dihydrate; 4-methylmorpholine N-oxide / water; tert-butyl alcohol / 72 h / 20 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium osmate dihydrate; potassium acetate; sodium carbonate; 4-methylmorpholine N-oxide; In tetrahydrofuran; water; dimethyl sulfoxide; tert-butyl alcohol;