benzyl (3S)-3-(1-propyn-1-yl)-4-(5-(1-(trifluoromethyl)ethenyl)-2-pyrimidinyl)-1-piperazinecarboxylate

Base Information

Chemical Name:benzyl (3S)-3-(1-propyn-1-yl)-4-(5-(1-(trifluoromethyl)ethenyl)-2-pyrimidinyl)-1-piperazinecarboxylate
CAS No.:1450620-45-7
Molecular Formula:C₂₂H₂₁F₃N₄O₂
Molecular Weight:430.43
Hs Code.:

Synonyms:benzyl (3S)-3-(1-propyn-1-yl)-4-(5-(1-(trifluoromethyl)ethenyl)-2-pyrimidinyl)-1-piperazinecarboxylate

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Chemical Property of benzyl (3S)-3-(1-propyn-1-yl)-4-(5-(1-(trifluoromethyl)ethenyl)-2-pyrimidinyl)-1-piperazinecarboxylate

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Technology Process of benzyl (3S)-3-(1-propyn-1-yl)-4-(5-(1-(trifluoromethyl)ethenyl)-2-pyrimidinyl)-1-piperazinecarboxylate

There total 10 articles about benzyl (3S)-3-(1-propyn-1-yl)-4-(5-(1-(trifluoromethyl)ethenyl)-2-pyrimidinyl)-1-piperazinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1514-82-5
2-bromo-3,3,3-trifluoropropene

: 1450620-46-8
C₂₅H₃₁BN₄O₄

: 1450620-45-7
benzyl (3S)-3-(1-propyn-1-yl)-4-(5-(1-(trifluoromethyl)ethenyl)-2-pyrimidinyl)-1-piperazinecarboxylate

Guidance literature:: C₂₅H₃₁BN₄O₄; With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In tetrahydrofuran; Sealed tube; Inert atmosphere;

2-bromo-3,3,3-trifluoropropene; In tetrahydrofuran; at 60 ℃; for 15h; Cooling with ice;

Reference yield:

: 1450620-44-6
benzyl (3S)-4-(5-bromo-2-pyrimidinyl)-3-(1-propyn-1-yl)-1-piperazinecarboxylate

: 1450620-45-7
benzyl (3S)-3-(1-propyn-1-yl)-4-(5-(1-(trifluoromethyl)ethenyl)-2-pyrimidinyl)-1-piperazinecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / dimethyl sulfoxide / 24 h / 100 °C / Inert atmosphere

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / tetrahydrofuran / Sealed tube; Inert atmosphere

2.2: 15 h / 60 °C / Cooling with ice

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; sodium carbonate; In tetrahydrofuran; dimethyl sulfoxide;

Reference yield:

: 1450620-14-0
4-benzyl 1-tert-butyl 2-(1-propyn-1-yl)-1,4-piperazinedicarboxylate

: 1450620-45-7
benzyl (3S)-3-(1-propyn-1-yl)-4-(5-(1-(trifluoromethyl)ethenyl)-2-pyrimidinyl)-1-piperazinecarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: Chiralpak^? ADH column / ethanol / Resolution of racemate

2.1: trifluoroacetic acid / dichloromethane / 0.67 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 22 h / 100 - 140 °C / Sealed tube

4.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / dimethyl sulfoxide / 24 h / 100 °C / Inert atmosphere

5.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / tetrahydrofuran / Sealed tube; Inert atmosphere

5.2: 15 h / 60 °C / Cooling with ice

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; sodium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; ethanol; dichloromethane; dimethyl sulfoxide;