5-[(2-amino-1,3-thiazol-4-yl)methyl]-4-phenyl-4H-1,2,4-triazole-3-thiol

Base Information

Chemical Name:5-[(2-amino-1,3-thiazol-4-yl)methyl]-4-phenyl-4H-1,2,4-triazole-3-thiol
CAS No.:198772-94-0
Molecular Formula:C₁₂H₁₁N₅S₂
Molecular Weight:289.385
Hs Code.:

Synonyms:5-[(2-amino-1,3-thiazol-4-yl)methyl]-4-phenyl-4H-1,2,4-triazole-3-thiol

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Chemical Property of 5-[(2-amino-1,3-thiazol-4-yl)methyl]-4-phenyl-4H-1,2,4-triazole-3-thiol

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Technology Process of 5-[(2-amino-1,3-thiazol-4-yl)methyl]-4-phenyl-4H-1,2,4-triazole-3-thiol

There total 6 articles about 5-[(2-amino-1,3-thiazol-4-yl)methyl]-4-phenyl-4H-1,2,4-triazole-3-thiol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 2-[2-(2-amino-1,3-thiazol-4-yl)acetyl]-N-phenyl-1-hydrazinecarbothioamide

: 198772-94-0
5-[(2-amino-1,3-thiazol-4-yl)methyl]-4-phenyl-4H-1,2,4-triazole-3-thiol

Guidance literature:: With sodium hydroxide; In water;
DOI:10.1016/j.bioorg.2019.01.036

Reference yield: 54.0%

: 198772-90-6
C₁₄H₁₅N₅O₂S₂

: 198772-94-0
5-[(2-amino-1,3-thiazol-4-yl)methyl]-4-phenyl-4H-1,2,4-triazole-3-thiol

Guidance literature:: With sodium hydroxide; for 4h; Heating;

Reference yield:

: 103-72-0
phenyl isothiocyanate

: 198772-94-0
5-[(2-amino-1,3-thiazol-4-yl)methyl]-4-phenyl-4H-1,2,4-triazole-3-thiol

Guidance literature:: Multi-step reaction with 2 steps

1: 75 percent / propan-2-ol / 4 h / Heating

2: 54 percent / aq. NaOH / 4 h / Heating

With sodium hydroxide; In isopropyl alcohol;