Ethyl 2-amino-4-thiazoleacetate

Base Information

• Chemical Name: Ethyl 2-amino-4-thiazoleacetate
• CAS No.: 53266-94-7
• Molecular Formula: C7H10N2O2S
• Molecular Weight: 186.235
• Hs Code.: 29349990
• European Community (EC) Number: 258-452-1
• UNII: 4LA52G9LVB
• DSSTox Substance ID: DTXSID10201389
• Nikkaji Number: J207.946A
• Wikidata: Q72472663
• ChEMBL ID: CHEMBL1492320
• Mol file: 53266-94-7.mol

Synonyms:53266-94-7;Ethyl 2-amino-4-thiazoleacetate;Ethyl 2-(2-aminothiazol-4-yl)acetate;ethyl 2-(2-amino-1,3-thiazol-4-yl)acetate;Ethyl 2-aminothiazole-4-acetate;Ethyl (2-Amino-4-thiazolyl)acetate;Ethyl (2-amino-1,3-thiazol-4-yl)acetate;MFCD00005330;4-Thiazoleacetic acid, 2-amino-, ethyl ester;Ethyl 2-aminothiazol-4-acetate;(2-Amino-4-thiazolyl)acetic acid ethyl ester;Ethyl 2-(2-aminothiazole-4-yl)acetate;ethyl 2-aminothiazol-4-ylacetate;EINECS 258-452-1;(2-Aminothiazol-4-yl)acetic acid ethyl ester;(2-amino-thiazol-4-yl)-acetic acid ethyl ester;ethyl 2-amino-4-thiazole acetate;EATA;Maybridge3_006161;Ethyl-2-(2-amino-4-thiazole-4-yl) acetate;SCHEMBL8445;4LA52G9LVB;Oprea1_589016;MLS000521344;ethy 2-aminothiazole-4-acetate;CHEMBL1492320;ethyl-2-amino-4-thiazoleacetate;SCHEMBL11011225;SHQNGLYXRFCPGZ-UHFFFAOYSA-;DTXSID10201389;ethyl 2-amino-4-thiazolylacetate;Ethyl 2-amino-4-thiazole-acetate;ethyl 2-amino-4-thiazolyl-acetate;HMS1448I01;HMS2450A11;AMY40145;BCP13751;ethyl (2-aminothiazol-4-yl)acetate;BBL004537;CCG-48529;STK182599;Ethyl2-(2-aminothiazol-4-yl)acetate;AKOS000119889;(4-Thiazolyl)acetic acid, ethyl ester;8M-580S;AC-5552;ethyl 2-(2-amino-4-thiazolyl)acetate;Ethyl 2-aminothiazole-4-acetate, 99%;IDI1_017548;NCGC00245964-01;SMR000131752;SY057166;2-amino-4-thiazoleacetic acid ethyl ester;2-amino-4-thiazolyl acetic acid ethyl ester;2-amino-4-thiazolyl acetic aicd ethyl ester;2-aminothiazol-4-yl acetic acid ethyl ester;A0955;BB 0217955;CS-0042665;EU-0066637;FT-0625852;EN300-16074;Ethyl (2-amino-1,3-thiazol-4-yl)acetate #;(2-amino-thiazol-4-yl)acetic acid ethyl ester;(2-aminothiazol-4-yl)-acetic acid ethyl ester;ethyl 2-(2-amino-1,3-thiazol-4-yl)-acetate;F30080;2-(2-aminothiazol-4-yl)-acetic acid ethyl ester;2-(2-Aminothiozole-4-yl)acetic acid ethyl ester;AB-601/30963022;ethyl 2-(2-imino-2,3-dihydrothiazol-4yl)acetate;SR-01000597199;(2-amino-1,3-thiazol-4-yl)acetic acid ethyl ester;2-(2-amino-thiazol-4-yl)-acetic acid ethyl ester;ethyl 2-(2-imino-2,3-dihydrothiazol-4-yl)acetate;SR-01000597199-1;SR-01000597199-2;W-105757;Z48847545;F0850-6741;ethyl 2-(2-imino-2,3-dihydro-1,3-thiazol-4-yl)acetate;53266-93-6

Chemical Property of Ethyl 2-amino-4-thiazoleacetate

Chemical Property:

• Appearance/Colour: slightly yellow to beige crystalline powder
• Vapor Pressure: 0.00036mmHg at 25°C
• Melting Point: 92-94 °C(lit.)
• Refractive Index: 1.575
• Boiling Point: 318.5 °C at 760 mmHg
• PKA: 3.72±0.10(Predicted)
• Flash Point: 146.4 °C
• PSA: 93.45000
• Density: 1.295 g/cm³
• LogP: 1.41210
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility.: soluble in Methanol
• XLogP3: 0.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 4
• Exact Mass: 186.04629874
• Heavy Atom Count: 12
• Complexity: 166

Purity/Quality:

99% ^*data from raw suppliers

Ethyl2-Amino-4-thiazoleacetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi, Xn
• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22
• Safety Statements: 37/39-26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CCOC(=O)CC1=CSC(=N1)N
• Uses: Ethyl 2-Amino-4-thiazoleacetate, is a versatile building block for the synthesis of various pharmaceutical and biologically active compounds including inhibitors and antibiotics. It is used in the synthesis of Cefdinir (C242675) derivatives.

Technology Process of Ethyl 2-amino-4-thiazoleacetate

There total 10 articles about Ethyl 2-amino-4-thiazoleacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-amino-4-thiazoleacetic acid (29676-71-9) + ethanol (64-17-5) → ethyl 2-amino-1,3-thiazol-4-acetate (53266-94-7)

Guidance literature:

With thionyl chloride; at 0 - 20 ℃; for 16h;

Reference yield: 79.0%

CYANAMID (420-04-2) + ethyl (2-chloroaceto)acetate (638-07-3) → ethyl 2-amino-1,3-thiazol-4-acetate (53266-94-7)

Guidance literature:

ethyl (2-chloroaceto)acetate; With pyrrolidine; toluene-4-sulfonic acid; In cyclohexane; water; for 3h; Reflux;

CYANAMID; With sulfur; In methanol; at 0 - 20 ℃; for 2h;

DOI:10.1002/jhet.2871

Reference yield: 78.0%

ethyl (2-chloroaceto)acetate (638-07-3) + thiourea (17356-08-0) → ethyl 2-amino-1,3-thiazol-4-acetate (53266-94-7)

Guidance literature:

In ethanol; for 4h; Reflux;

upstream raw materials:

2-amino-4-thiazoleacetic acid

ethanol

ethyl (2-chloroaceto)acetate

thiourea

Downstream raw materials:

{2-[(N-acetyl-sulfanilyl)-amino]-thiazol-4-yl}-acetic acid ethyl ester

ethyl 2-(2-bromo-1,3-thiazol-4-yl)acetate

{2-imino-3-[2-(4-nitro-phenyl)-2-oxo-ethyl]-2,3-dihydro-thiazol-4-yl}-acetic acid ethyl ester

[2-[(triphenyl-methyl)-amino]-thiazol-4-yl] acetic acid