methyl 2,6-difluoro-3-(N-(3-fluoropropylsulfonyl)-3-fluoro-propylsulfonamido)benzoate

Base Information

• Chemical Name: methyl 2,6-difluoro-3-(N-(3-fluoropropylsulfonyl)-3-fluoro-propylsulfonamido)benzoate
• CAS No.: 1186194-06-8
• Molecular Formula: C₁₄H₁₇F₄NO₆S₂
• Molecular Weight: 435.418
• Mol file: 1186194-06-8.mol

Synonyms:methyl 2,6-difluoro-3-(N-(3-fluoropropylsulfonyl)-3-fluoro-propylsulfonamido)benzoate

Chemical Property of methyl 2,6-difluoro-3-(N-(3-fluoropropylsulfonyl)-3-fluoro-propylsulfonamido)benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2,6-difluoro-3-(N-(3-fluoropropylsulfonyl)-3-fluoro-propylsulfonamido)benzoate

There total 4 articles about methyl 2,6-difluoro-3-(N-(3-fluoropropylsulfonyl)-3-fluoro-propylsulfonamido)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-fluoropropane-1-sulfonyl chloride (461-28-9) + methyl 3-amino-2,6-difluorobenzoate (84832-02-0) → methyl 2,6-difluoro-3-(N-(3-fluoropropylsulfonyl)-3-fluoro-propylsulfonamido)benzoate (1186194-06-8)

Guidance literature:

With pyridine; In dichloromethane; at 20 ℃; for 48h; Product distribution / selectivity;

Reference yield:

2,6-difluoro-3-nitrobenzoic acid (83141-10-0) → methyl 2,6-difluoro-3-(N-(3-fluoropropylsulfonyl)-3-fluoro-propylsulfonamido)benzoate (1186194-06-8)

Guidance literature:

Multi-step reaction with 3 steps

1: methanol / hexanes / 2 h / Cooling with water

2: hydrogen / palladium 10% on activated carbon / ethanol / Inert atmosphere

3: pyridine / dichloromethane / 48 h / 20 °C

With pyridine; methanol; hydrogen; palladium 10% on activated carbon; In hexanes; ethanol; dichloromethane;

Reference yield:

methyl 2,6-difluoro-3-nitrobenzoate (84832-01-9) → methyl 2,6-difluoro-3-(N-(3-fluoropropylsulfonyl)-3-fluoro-propylsulfonamido)benzoate (1186194-06-8)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen / palladium 10% on activated carbon / ethanol / Inert atmosphere

2: pyridine / dichloromethane / 48 h / 20 °C

With pyridine; hydrogen; palladium 10% on activated carbon; In ethanol; dichloromethane;

upstream raw materials:

3-fluoropropane-1-sulfonyl chloride

methyl 3-amino-2,6-difluorobenzoate

2,6-difluoro-3-nitrobenzoic acid

methyl 2,6-difluoro-3-nitrobenzoate

Downstream raw materials:

2,6-difluoro-3-(3-fluoropropylsulfonamido)benzoic acid

2,6-difluoro-3-(3-fluoropropylsulfonamido)-N-(3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)benzamide

N-(3-cyclopropyl-1H-pyrazolo[3,4-b]pyridin-5-yl)-2,6-difluoro-3-(3-fluoropropylsulfonamido)benzamide