3-Fluoro-1-propanesulfonyl chloride

Base Information

• Chemical Name: 3-Fluoro-1-propanesulfonyl chloride
• CAS No.: 461-28-9
• Molecular Formula: C3H6ClFO2S
• Molecular Weight: 160.597
• Mol file: 461-28-9.mol

Synonyms:3-fluoropropylsulfonyl chloride;3-fluoropropyl sulfurochloridoite;3-Fluor-propan-1-sulfonylchlorid;3-fluoro-propane-1-sulfonyl chloride;3-fluoropropanesulfonyl chloride;3-Fluoropropanesulphonyl chloride;Propanesulfonyl chloride,3-fluoro;

Chemical Property of 3-Fluoro-1-propanesulfonyl chloride

Chemical Property:

• Vapor Pressure: 0.163mmHg at 25°C
• Refractive Index: 1.4481
• Boiling Point: 221°Cat760mmHg
• Flash Point: 87.4°C
• PSA: 45.51000
• Density: 1.449g/cm³
• LogP: 2.04580

Purity/Quality:

97% ^*data from raw suppliers

3-fluoropropane-1-sulfonylchloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Fluoro-1-propanesulfonyl chloride

There total 2 articles about 3-Fluoro-1-propanesulfonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

(3-fluoropropyl)ethanethioate (1033906-64-7) → 3-fluoropropane-1-sulfonyl chloride (461-28-9)

Guidance literature:

With chlorine; In dichloromethane; water; at -20 ℃; for 5h;

Reference yield: 31.0%

3-fluoropropyl thiocyanate (408-00-4) → 3-fluoropropane-1-sulfonyl chloride (461-28-9)

Guidance literature:

With water; chlorine; In acetic acid; for 0.0833333h;

DOI:10.3762/bjoc.9.115

Reference yield: 99.0%

3-fluoropropane-1-sulfonyl chloride (461-28-9) + 2-chloro-3-nitroaniline (3970-41-0) → N-(2-chloro-3-nitrophenyl)-3-fluoro-N-((3-fluoropropyl)sulfonyl)propane-1-sulfonamide

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 2.5h;

upstream raw materials:

3-fluoropropyl thiocyanate

(3-fluoropropyl)ethanethioate

Downstream raw materials:

3-fluoro-propane-1-sulfonyl fluoride

1-(3-fluoropropylsulfonyl)-4-(2-methoxyphenyl)piperazine

ethyl (S)-2-(3-fluoropropylsulfonamido)-3-phenylpropanoate

methyl 2,6-difluoro-3-(N-(3-fluoropropylsulfonyl)-3-fluoro-propylsulfonamido)benzoate