tert-butyl ((1s,3s)-3-(difluoro(phenylsulfonyl)methyl)-3-hydroxycyclobutyl)carbamate

Base Information

Chemical Name:tert-butyl ((1s,3s)-3-(difluoro(phenylsulfonyl)methyl)-3-hydroxycyclobutyl)carbamate
CAS No.:1352343-02-2
Molecular Formula:C₁₆H₂₁F₂NO₅S
Molecular Weight:377.409
Hs Code.:

Synonyms:tert-butyl ((1s,3s)-3-(difluoro(phenylsulfonyl)methyl)-3-hydroxycyclobutyl)carbamate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tert-butyl ((1s,3s)-3-(difluoro(phenylsulfonyl)methyl)-3-hydroxycyclobutyl)carbamate

Chemical Property:

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Technology Process of tert-butyl ((1s,3s)-3-(difluoro(phenylsulfonyl)methyl)-3-hydroxycyclobutyl)carbamate

There total 1 articles about tert-butyl ((1s,3s)-3-(difluoro(phenylsulfonyl)methyl)-3-hydroxycyclobutyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 154748-49-9
3-(tert-butyloxycarbonylamino)cyclobutan-1-one

: 1535-65-5
difluoromethyl phenyl sulfone

: 1352343-02-2
tert-butyl ((1s,3s)-3-(difluoro(phenylsulfonyl)methyl)-3-hydroxycyclobutyl)carbamate

Guidance literature:: With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 2h;
DOI:10.1021/jm401646w

Reference yield:

: 1352343-02-2
tert-butyl ((1s,3s)-3-(difluoro(phenylsulfonyl)methyl)-3-hydroxycyclobutyl)carbamate

: 1443644-47-0
O-phenyl ((1s,3s)-3-(difluoromethyl)-3-hydroxycyclobutyl)carbamothioate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium amalgam; disodium hydrogenphosphate / methanol

2: trifluoroacetic acid / dichloromethane

3: triethylamine / dichloromethane

With disodium hydrogenphosphate; sodium amalgam; triethylamine; trifluoroacetic acid; In methanol; dichloromethane;
DOI:10.1021/jm401646w