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1535-65-5

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1535-65-5 Usage

Chemical Properties

light yellow liquid

Uses

Different sources of media describe the Uses of 1535-65-5 differently. You can refer to the following data:
1. Efficient reagent for difluoromethylation of carbonyls and aldehydes.
2. Difluoromethyl Phenyl Sulfone has been used as a reagent for the nucleophilic difluoro(phenylsulfonyl)methylation of carbonyls

Check Digit Verification of cas no

The CAS Registry Mumber 1535-65-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,5,3 and 5 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1535-65:
(6*1)+(5*5)+(4*3)+(3*5)+(2*6)+(1*5)=75
75 % 10 = 5
So 1535-65-5 is a valid CAS Registry Number.
InChI:InChI=1S/C7H6F2O2S/c8-7(9)12(10,11)6-4-2-1-3-5-6/h1-5,7H

1535-65-5 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • TCI America

  • (D4764)  Difluoromethyl Phenyl Sulfone  >98.0%(GC)

  • 1535-65-5

  • 1g

  • 690.00CNY

  • Detail
  • TCI America

  • (D4764)  Difluoromethyl Phenyl Sulfone  >98.0%(GC)

  • 1535-65-5

  • 5g

  • 2,750.00CNY

  • Detail
  • Alfa Aesar

  • (H64760)  Difluoromethyl phenyl sulfone, 95%   

  • 1535-65-5

  • 250mg

  • 216.0CNY

  • Detail
  • Alfa Aesar

  • (H64760)  Difluoromethyl phenyl sulfone, 95%   

  • 1535-65-5

  • 1g

  • 648.0CNY

  • Detail
  • Alfa Aesar

  • (H64760)  Difluoromethyl phenyl sulfone, 95%   

  • 1535-65-5

  • 5g

  • 2594.0CNY

  • Detail
  • Aldrich

  • (742600)  Difluoromethyl phenyl sulfone  ≥97%

  • 1535-65-5

  • 742600-1G

  • 788.58CNY

  • Detail
  • Aldrich

  • (742600)  Difluoromethyl phenyl sulfone  ≥97%

  • 1535-65-5

  • 742600-10G

  • 6,657.30CNY

  • Detail

1535-65-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name ((Difluoromethyl)sulfonyl)benzene

1.2 Other means of identification

Product number -
Other names Difluoromethyl Phenyl Sulfone

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1535-65-5 SDS

1535-65-5Relevant articles and documents

-

Hine,J.,Porter,J.J.

, p. 6178 - 6181 (1960)

-

Regio- and chemoselectivity in S- and O- difluoromethylation reactions using diethyl (bromodifluoromethyl)phosphonate

Amir, Dafna,Binyamin, Iris,Drug, Eyal,Fridkin, Gil,Gershonov, Eytan,Marciano, Daniele,Redy-Keisar, Orit,Yehezkel, Lea,Zafrani, Yossi

, (2021/09/08)

The effective difluoromethylations of various S- and O- based- nucleophiles, presenting a wide range of pKa values, using diethyl(bromodifluoromethyl) phosphonate (1) under basic conditions is described. These reactions, which rely on the quantitative generation of difluorocarbene formed through the hydrolysis of 1, were found to be effective only once the starting materials had pKa values of less than ca. 11. Importantly, in cases in which the substrates held two or three nucleophilic centers this feature was successfully implemented to achieve a high chemo- or regioselective difluoromethylation of the center exhibiting the lowest pKa value and the highest polarizability.

Preparation method of difluoromethyl sulfone compound

-

Paragraph 0088-0113; 0119-0121, (2021/03/31)

The invention discloses a preparation method of a difluoromethyl sulfone compound. The invention provides a preparation method of a difluoromethyl sulfone compound, which comprises the following step:in a solvent, in the presence of alkali and a phase transfer catalyst, carrying out difluoromethylation reaction shown in the specification on sulfinic acid and/or salt thereof and CHClF2 to obtain the difluoromethyl sulfone compound. The solvent is a mixed solvent of water and an organic solvent; The sulfinic acid and/or salt thereof comprises positive ions and negative ions, and the negative ions contain structural fragments shown as a formula I; and the difluoromethyl sulfone compound contains a structural fragment as shown in a formula II which is described in the specification. The preparation method provided by the invention has the advantages of accessible raw materials, wide substrate range, mild reaction conditions and simple operation, can implement separation without column chromatography, and is suitable for industrial production. The difluoromethyl sulfone compound can be obtained at a high yield.

Nucleophilic (Phenylsulfonyl/arylthio)difluoromethylation of Aldehydes with TMSCF2Br: A Three-Component Strategy

Xie, Qiqiang,Zhu, Ziyue,Ni, Chuanfa,Hu, Jinbo

, p. 9138 - 9141 (2019/11/14)

An efficient method for nucleophilic (phenylsulfonyl/arylthio)difluoromethylation of aldehydes with TMSCF2Br was developed. The reaction proceeds through in situ generation of difluorocarbene, which is captured by PhSO2Na or ArSNa to

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