oxime de la methyl-2 phenyl-1 (hydroxy-1 cyclopentyl)-2 propanone-1 syn

Base Information

• Chemical Name: oxime de la methyl-2 phenyl-1 (hydroxy-1 cyclopentyl)-2 propanone-1 syn
• CAS No.: 107449-88-7
• Molecular Formula: C₁₅H₂₁NO₂
• Molecular Weight: 247.337
• Mol file: 107449-88-7.mol

Synonyms:oxime de la methyl-2 phenyl-1 (hydroxy-1 cyclopentyl)-2 propanone-1 syn

Chemical Property of oxime de la methyl-2 phenyl-1 (hydroxy-1 cyclopentyl)-2 propanone-1 syn

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of oxime de la methyl-2 phenyl-1 (hydroxy-1 cyclopentyl)-2 propanone-1 syn

There total 2 articles about oxime de la methyl-2 phenyl-1 (hydroxy-1 cyclopentyl)-2 propanone-1 syn which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 2,2-dimethyl-3-oxo-3-phenylpropionate (25491-42-3) → oxime de la methyl-2 phenyl-1 (hydroxy-1 cyclopentyl)-2 propanone-1 syn (107449-88-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 63 percent / hydroxylamine hydrochloride, NaCO₃ / H₂O / 0 - 10 °C

2: 1.) Mg / 1.) THF, RT, 4 h, 2.) RT

With hydroxylamine hydrochloride; magnesium; In water;

DOI:10.1016/S0040-4020(01)87644-4

Reference yield:

1,4-dibromo-butane (110-52-1) + 3-phenyl-4,4-dimethyl-5-oxo-2-isoxazoline (51942-54-2) → oxime de la methyl-2 phenyl-1 (hydroxy-1 cyclopentyl)-2 propanone-1 syn (107449-88-7)

Guidance literature:

With magnesium; Yield given. Multistep reaction; 1.) THF, RT, 4 h, 2.) RT;

DOI:10.1016/S0040-4020(01)87644-4

Reference yield: 71.0%

oxime de la methyl-2 phenyl-1 (hydroxy-1 cyclopentyl)-2 propanone-1 syn (107449-88-7) → methyl-2 phenyl-1 (hydroxy-1 cyclopentyl)-2 propanone-1 (107449-99-0)

Guidance literature:

With ammonium acetate; titanium(III) chloride; acetic acid; In acetone;

DOI:10.1016/S0040-4020(01)87644-4

upstream raw materials:

1,4-dibromo-butane

3-phenyl-4,4-dimethyl-5-oxo-2-isoxazoline

ethyl 2,2-dimethyl-3-oxo-3-phenylpropionate

Downstream raw materials:

methyl-2 phenyl-1 (hydroxy-1 cyclopentyl)-2 propanone-1

dimethyl-4,4 phenyl-3 oxa-1 aza-2 spiro<4.4>nonene-2