51942-54-2

Basic information

• Product Name: 3-phenyl-4,4-dimethyl-5-oxo-2-isoxazoline
• Synonyms: 3-phenyl-4,4-dimethyl-5-oxo-2-isoxazoline
• CAS NO: 51942-54-2
• Molecular Weight: 189.214
• Mol File: 51942-54-2.mol

Chemical Properties

• CAS DataBase Reference: 3-phenyl-4,4-dimethyl-5-oxo-2-isoxazoline(CAS DataBase Reference)
• NIST Chemistry Reference: 3-phenyl-4,4-dimethyl-5-oxo-2-isoxazoline(51942-54-2)
• EPA Substance Registry System: 3-phenyl-4,4-dimethyl-5-oxo-2-isoxazoline(51942-54-2)

Safety Data

• Hazardous Substances Data: 51942-54-2(Hazardous Substances Data)

Upstream product

• 25491-42-3 ethyl 2,2-dimethyl-3-oxo-3-phenylpropionate 
• 1750-74-9 2-benzoyl-2-methylpropanal 
• 64407-08-5 methyl 2,2-dimethyl-3-oxo-3-phenylpropanoate 
• 611-70-1 phenyl isopropyl ketone 
• 546-67-8 lead(IV) tetraacetate 
• 99390-62-2 α-benzoylisobutyraldehyde dioxime 

Downstream Products

• 51942-51-9 3-Phenyl-4.4.5-trimethyl-5-hydroxy-isoxazolin 
• 51942-52-0 4,4-dimethyl-3,5-diphenyl-4,5-dihydroisoxazol-5-ol 
• 51942-50-8 3-phenyl-4,4-dimethyl-5-hydroxy-2-isoxazoline 
• 1257846-47-1 1-isopropyl-4-methyl-3-phenylisoquinoline 
• 1257846-45-9 1-iso-propyl-3,4-diphenylisoquinoline 
• 1257846-46-0 C₂₄H₂₀⁽²⁾HN 
• 100-42-5 styrene 
• 14491-02-2 2,2-dimethyl-3-phenyl-2H-azirine 
• 75-05-8 acetonitrile 
• 14016-34-3 N-(2-methyl-1-propenylidene)aniline 
• 7420-86-2 5-methyl-2-phenyl-1,3-benzoxazole 
• 5998-51-6 5-(tert-butyl)-2-phenylbenzo[d]oxazole 
• 65407-95-6 2,5-diphenylbenzo[d]oxazole 
• 1239752-32-9 ethyl 5-carboxylic acid-2-phenylbenzoxazole 

Relevant articles and documents

Dioxygen Activation via Cu-Catalyzed Cascade Radical Reaction: An Approach to Isoxazoline/Cyclic Nitrone-Featured α-Ketols

A facile, mild, and efficient dioxygen activation for the synthesis of isoxazoline/cyclic nitrone-featured α-ketols has been achieved by Cu-catalyzed trifunctionalization of internal unactivated alkynes of unsaturated ketoximes at room temperature. 18O isotope tracing and DFT calculation reveal that a cascade iminoxyl radical dichotomous 5-exo-dig cyclization/oxygen activation/peroxy radical 4-endo-trig cyclization process was involved in the reaction.

Cu-Catalyzed Synthesis of Benzoxazole with Phenol and Cyclic Oxime

A Cu-catalyzed straightforward synthesis of benzoxazoles from free phenols and cyclic oxime esters is reported. The mild reaction conditions tolerate various electron-withdrawing and electron-donating functional groups on both substrates, affording benzoxazoles in moderate to good yields. With this protocol, large-scale syntheses of Ezutromid and Flunoxaprofe in one or two steps are demonstrated. A catalytic mechanism, which includes Cu-catalyzed amination via inner-sphere electron transfer and consequent annulation, is proposed.

Palladium Catalyzed Ring Expansion Reaction of Isoxazolones with Isocyanides: Synthesis of 1,3-Oxazin-6-One Derivatives

A palladium catalyzed ring expansion reaction of isoxazolones with isocyanides was disclosed. In the reaction, a cascade process involving ring-opening/cyclization was suggested. The reaction features high atomic economy due to no elimination of CO2 occurred. Moreover, products obtained demonstrate aggregation-induced emission properties with relatively high solid-state emission efficiencies. (Figure presented.).

Palladium-catalyzed aza-wittig-type condensation of isoxazol-5(4H)-ones with aldehydes

This paper describes the development of a palladium-catalyzed decarboxylative inter- and intramolecular condensation reaction of isoxazol-5(4 H)-ones with carbonyl compounds in the presence of PPh3, giving various 2-azabuta-1,3-dienes or pyrrol

Rhodium(III)-catalyzed synthesis of isoquinolines from aryl ketone o -acyloxime derivatives and internal alkynes

A synthetic method of isoquinolines from aryl ketone O-acyloxime derivatives and internal alkynes has been developed using [Cp*RhCl 2]2 - NaOAc as the potential catalyst system. The present transformation is carried out by a redox-neutral sequence of C - H vinylation via ortho-rhodation and C - N bond formation of the putative vinyl rhodium intermediate on the oxime nitrogen, where the N - O bond of oxime derivatives could work as an internal oxidant to maintain the catalytic cycle.

ETUDE DES REACTIONS DU DI(BROMOMAGNESIO)-1,4 BUTANE ET DU DI(BROMOMAGNESIO)-1,5 PENTANE SUR LES ISOXAZOLONES-5 ENCOMBREES

Oximes of 1-methyl and 1-phenyl-3(hydroxycyclopentyl)-2-alkanones were prepared in one step with high yield, from 1,4-bis(bromomagnesio)butane and 5-isoxazolones in tetrahydrofuran.This reaction was found to be general and applicable to any hindered 5-iso

Oxidative cyclization of some 1,3-Dioximes with Lead Tetraacetate

Oxidation of 1,3-dioximes 1 with lead tetraacetate gives di-N-oxides of pyrazolines 4 or pyrazoles 5 or N-oxides of oxadiazines 7 as the main reaction products.The reaction mechanism is discussed.