3-{4-[2-(5-methyl-2-thiophen-2-yl-oxazol-4-yl)-ethoxy]-phenyl}-propionitrile

Base Information

• Chemical Name: 3-{4-[2-(5-methyl-2-thiophen-2-yl-oxazol-4-yl)-ethoxy]-phenyl}-propionitrile
• CAS No.: 166253-31-2
• Molecular Formula: C₁₉H₁₈N₂O₂S
• Molecular Weight: 338.43

Synonyms:3-{4-[2-(5-methyl-2-thiophen-2-yl-oxazol-4-yl)-ethoxy]-phenyl}-propionitrile

Chemical Property of 3-{4-[2-(5-methyl-2-thiophen-2-yl-oxazol-4-yl)-ethoxy]-phenyl}-propionitrile

Chemical Property:

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Technology Process of 3-{4-[2-(5-methyl-2-thiophen-2-yl-oxazol-4-yl)-ethoxy]-phenyl}-propionitrile

There total 2 articles about 3-{4-[2-(5-methyl-2-thiophen-2-yl-oxazol-4-yl)-ethoxy]-phenyl}-propionitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

(E)-3-{4-[2-(5-Methyl-2-thiophen-2-yl-oxazol-4-yl)-ethoxy]-phenyl}-acrylonitrile (166253-24-3) → 3-{4-[2-(5-methyl-2-thiophen-2-yl-oxazol-4-yl)-ethoxy]-phenyl}-propionitrile (166253-31-2)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethyl acetate; under 760 Torr;

DOI:10.1248/cpb.50.100

Reference yield:

4-[2-[5-methyl-2-(2-thienyl)-4-oxazolyl]ethoxy]benzaldehyde (103789-62-4) → 3-{4-[2-(5-methyl-2-thiophen-2-yl-oxazol-4-yl)-ethoxy]-phenyl}-propionitrile (166253-31-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: NaH / tetrahydrofuran / 0.25 h

1.2: 48 percent / tetrahydrofuran

2.1: 77 percent / H₂ / 5 percent Pd/C / ethyl acetate / 760 Torr

With hydrogen; sodium hydride; palladium on activated charcoal; In tetrahydrofuran; ethyl acetate;

DOI:10.1248/cpb.50.100

Reference yield: 47.0%

3-{4-[2-(5-methyl-2-thiophen-2-yl-oxazol-4-yl)-ethoxy]-phenyl}-propionitrile (166253-31-2) → 5-(2-{4-[2-(5-methyl-2-thiophen-2-yl-oxazol-4-yl)-ethoxy]-phenyl}-ethyl)-1H-tetrazole

Guidance literature:

With sodium azide; ammonium chloride; In N,N-dimethyl-formamide; at 120 ℃;

DOI:10.1248/cpb.50.100

upstream raw materials:

(E)-3-{4-[2-(5-Methyl-2-thiophen-2-yl-oxazol-4-yl)-ethoxy]-phenyl}-acrylonitrile

4-[2-[5-methyl-2-(2-thienyl)-4-oxazolyl]ethoxy]benzaldehyde

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