(E)-3-{4-[2-(5-Methyl-2-thiophen-2-yl-oxazol-4-yl)-ethoxy]-phenyl}-acrylonitrile

Base Information

Chemical Name:(E)-3-{4-[2-(5-Methyl-2-thiophen-2-yl-oxazol-4-yl)-ethoxy]-phenyl}-acrylonitrile
CAS No.:166253-24-3
Molecular Formula:C₁₉H₁₆N₂O₂S
Molecular Weight:336.414
Hs Code.:

Synonyms:(E)-3-{4-[2-(5-Methyl-2-thiophen-2-yl-oxazol-4-yl)-ethoxy]-phenyl}-acrylonitrile

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Chemical Property of (E)-3-{4-[2-(5-Methyl-2-thiophen-2-yl-oxazol-4-yl)-ethoxy]-phenyl}-acrylonitrile

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Technology Process of (E)-3-{4-[2-(5-Methyl-2-thiophen-2-yl-oxazol-4-yl)-ethoxy]-phenyl}-acrylonitrile

There total 1 articles about (E)-3-{4-[2-(5-Methyl-2-thiophen-2-yl-oxazol-4-yl)-ethoxy]-phenyl}-acrylonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 2537-48-6
diethyl 1-cyanomethylphosphonate

: 103789-62-4
4-[2-[5-methyl-2-(2-thienyl)-4-oxazolyl]ethoxy]benzaldehyde

: 166253-24-3
(E)-3-{4-[2-(5-Methyl-2-thiophen-2-yl-oxazol-4-yl)-ethoxy]-phenyl}-acrylonitrile

Guidance literature:: diethyl 1-cyanomethylphosphonate; With sodium hydride; In tetrahydrofuran; for 0.25h;

4-[2-[5-methyl-2-(2-thienyl)-4-oxazolyl]ethoxy]benzaldehyde; In tetrahydrofuran;
DOI:10.1248/cpb.50.100

Reference yield: 77.0%

: 166253-24-3
(E)-3-{4-[2-(5-Methyl-2-thiophen-2-yl-oxazol-4-yl)-ethoxy]-phenyl}-acrylonitrile

: 166253-31-2
3-{4-[2-(5-methyl-2-thiophen-2-yl-oxazol-4-yl)-ethoxy]-phenyl}-propionitrile

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate; under 760 Torr;
DOI:10.1248/cpb.50.100

Reference yield:

: 166253-24-3
(E)-3-{4-[2-(5-Methyl-2-thiophen-2-yl-oxazol-4-yl)-ethoxy]-phenyl}-acrylonitrile

: 5-(2-{4-[2-(5-methyl-2-thiophen-2-yl-oxazol-4-yl)-ethoxy]-phenyl}-ethyl)-1H-tetrazole

Guidance literature:: Multi-step reaction with 2 steps

1: 77 percent / H₂ / 5 percent Pd/C / ethyl acetate / 760 Torr

2: 47 percent / NaN₃; NH₄Cl / dimethylformamide / 120 °C

With sodium azide; hydrogen; ammonium chloride; palladium on activated charcoal; In ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1248/cpb.50.100