1'',2'-Di-epi-perindopril, (1''R,2'R)-

Base Information

Chemical Name:1'',2'-Di-epi-perindopril, (1''R,2'R)-
CAS No.:145513-54-8
Molecular Formula:C₁₉H₃₂N₂O₅
Molecular Weight:368.473
Hs Code.:
UNII:NYV8FIT0GU,B3BW33MUFM

Synonyms:UNII-B3BW33MUFM;B3BW33MUFM;1'',2'-Di-epi-perindopril, (1''R,2'R)-;145513-54-8;1H-Indole-2-carboxylic acid, 1-(2-((1-(ethoxycarbonyl)butyl)amino)-1-oxopropyl)octahydro-, (2S-(1(S*(S*)),2alpha,3abeta,7abeta))-;NYV8FIT0GU;SCHEMBL8270295;(+/-)-1'',2'-DI-EPI-PERINDOPRIL;1'',2'-DI-EPI-PERINDOPRIL, (+/-)-;PERINDOPRIL TERT-BUTYLAMINE IMPURITY T [EP IMPURITY];(2RS,3ARS,7ARS)-1-((2SR)-2-(((1SR)-1-(ETHOXYCARBONYL)BUTYL)AMINO)PROPANOYL)OCTAHYDRO-1H-INDOLE-2-CARBOXYLIC ACID;1H-INDOLE-2-CARBOXYLIC ACID, 1-(2-((1-(ETHOXYCARBONYL)BUTYL)AMINO)-1-OXOPROPYL)OCTAHYDRO-, (2S-(1(S*(S*)),2.ALPHA.,3A.BETA.,7A.BETA.))-

Suppliers and Price of 1'',2'-Di-epi-perindopril, (1''R,2'R)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 1'',2'-Di-epi-perindopril, (1''R,2'R)-

Chemical Property:

XLogP3:0.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:9
Exact Mass:368.23112213
Heavy Atom Count:26
Complexity:524

Purity/Quality:: 95%+ or 98%+ ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCCC(C(=O)OCC)NC(C)C(=O)N1C2CCCCC2CC1C(=O)O
Isomeric SMILES:CCC[C@H](C(=O)OCC)N[C@H](C)C(=O)N1[C@H]2CCCC[C@H]2C[C@H]1C(=O)O

Technology Process of 1'',2'-Di-epi-perindopril, (1''R,2'R)-

There total 9 articles about 1'',2'-Di-epi-perindopril, (1''R,2'R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 82864-25-3,79799-34-1
ethyl (2S,3aS,7aS)-octahydro-1H-indole-2-carboxylate hydrochloride

: 145513-54-8,145513-33-3,82978-68-5,99149-83-4
1-<(2S) 2-<((1S) 1-carbethoxybutyl) amino> 1-oxo propyl> (2S, 3aS, 7aS) perhydroindole 2-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: NaOH / H₂O; ethanol / 25 °C

2: NEt₃ / CH₂Cl₂; benzene

3: H₂SO₄

4: hydrogen / Pd/C / ethanol

5: NEt₃, HOBT, DCC / dimethylformamide

With sodium hydroxide; sulfuric acid; hydrogen; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In ethanol; dichloromethane; water; N,N-dimethyl-formamide; benzene;
DOI:10.1016/S0040-4039(00)87188-9

Reference yield:

: 79854-42-5
Ethyl (S)-indoline-2-carboxylate hydrochloride

: 145513-54-8,145513-33-3,82978-68-5,99149-83-4
1-<(2S) 2-<((1S) 1-carbethoxybutyl) amino> 1-oxo propyl> (2S, 3aS, 7aS) perhydroindole 2-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1: hydrogen / Pd/C / ethanol

2: NaOH / H₂O; ethanol / 25 °C

3: NEt₃ / CH₂Cl₂; benzene

4: H₂SO₄

5: hydrogen / Pd/C / ethanol

6: NEt₃, HOBT, DCC / dimethylformamide

With sodium hydroxide; sulfuric acid; hydrogen; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In ethanol; dichloromethane; water; N,N-dimethyl-formamide; benzene;
DOI:10.1016/S0040-4039(00)87188-9

Reference yield:

: 80875-98-5,2055118-14-2
(2S,3aS,7aS)-perhydroindole-2-carboxylic acid

: 145513-54-8,145513-33-3,82978-68-5,99149-83-4
1-<(2S) 2-<((1S) 1-carbethoxybutyl) amino> 1-oxo propyl> (2S, 3aS, 7aS) perhydroindole 2-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: NEt₃ / CH₂Cl₂; benzene

2: H₂SO₄

3: hydrogen / Pd/C / ethanol

4: NEt₃, HOBT, DCC / dimethylformamide

With sulfuric acid; hydrogen; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide; benzene;
DOI:10.1016/S0040-4039(00)87188-9