N-[2-(tert-butyldimethylsilyloxymethyl)allyl]-N-tert-butoxycarbonyl-(4-fluorophenyl)ethynylamine

Base Information

Chemical Name:N-[2-(tert-butyldimethylsilyloxymethyl)allyl]-N-tert-butoxycarbonyl-(4-fluorophenyl)ethynylamine
CAS No.:1429308-95-1
Molecular Formula:C₂₃H₃₄FNO₃Si
Molecular Weight:419.612
Hs Code.:

Synonyms:N-[2-(tert-butyldimethylsilyloxymethyl)allyl]-N-tert-butoxycarbonyl-(4-fluorophenyl)ethynylamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[2-(tert-butyldimethylsilyloxymethyl)allyl]-N-tert-butoxycarbonyl-(4-fluorophenyl)ethynylamine

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Technology Process of N-[2-(tert-butyldimethylsilyloxymethyl)allyl]-N-tert-butoxycarbonyl-(4-fluorophenyl)ethynylamine

There total 3 articles about N-[2-(tert-butyldimethylsilyloxymethyl)allyl]-N-tert-butoxycarbonyl-(4-fluorophenyl)ethynylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 1361493-73-3
tert-butyl (2-({(tert-butyl(dimethyl)silyl)oxy}methyl)prop-2-en-1-yl)carbamate

: 95895-33-3
1-(bromoethynyl)-4-fluorobenzene

: 1429308-95-1
N-[2-(tert-butyldimethylsilyloxymethyl)allyl]-N-tert-butoxycarbonyl-(4-fluorophenyl)ethynylamine

Guidance literature:: With potassium phosphate; 1,10-Phenanthroline; copper(ll) sulfate pentahydrate; In toluene; for 48h; Inert atmosphere; Reflux;
DOI:10.3762/bjoc.8.250

Reference yield:

: 116700-73-3
2-(tert-butyl-dimethyl-silanyloxymethyl)-prop-2-en-1-ol

: 1429308-95-1
N-[2-(tert-butyldimethylsilyloxymethyl)allyl]-N-tert-butoxycarbonyl-(4-fluorophenyl)ethynylamine

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / tetrahydrofuran / 1.5 h / -40 °C / Inert atmosphere

2.1: N,N-dimethyl-formamide / 90 °C / Inert atmosphere

3.1: hydrazine hydrate / ethanol / Reflux; Inert atmosphere

3.2: 20 °C / Inert atmosphere

4.1: copper(ll) sulfate pentahydrate; 1,10-Phenanthroline; potassium phosphate / toluene / 48 h / Inert atmosphere; Reflux

With potassium phosphate; 1,10-Phenanthroline; copper(ll) sulfate pentahydrate; hydrazine hydrate; triethylamine; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; toluene;
DOI:10.3762/bjoc.8.250

Reference yield:

: 2-(2-(((tert-butyldimethylsilyl)oxy)methyl)allyl)isoindoline-1,3-dione

: 1429308-95-1
N-[2-(tert-butyldimethylsilyloxymethyl)allyl]-N-tert-butoxycarbonyl-(4-fluorophenyl)ethynylamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrazine hydrate / ethanol / Reflux; Inert atmosphere

1.2: 20 °C / Inert atmosphere

2.1: copper(ll) sulfate pentahydrate; 1,10-Phenanthroline; potassium phosphate / toluene / 48 h / Inert atmosphere; Reflux

With potassium phosphate; 1,10-Phenanthroline; copper(ll) sulfate pentahydrate; hydrazine hydrate; In ethanol; toluene;
DOI:10.3762/bjoc.8.250