95895-33-3

Basic information

• Product Name: Benzene, 1-(bromoethynyl)-4-fluoro-
• CAS NO: 95895-33-3
• Molecular Formula: C8H4BrF
• Molecular Weight: 199.022
• Mol File: 95895-33-3.mol
• Article Data: 46

Chemical Properties

• CAS DataBase Reference: Benzene, 1-(bromoethynyl)-4-fluoro-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-(bromoethynyl)-4-fluoro-(95895-33-3)
• EPA Substance Registry System: Benzene, 1-(bromoethynyl)-4-fluoro-(95895-33-3)

Safety Data

• Hazardous Substances Data: 95895-33-3(Hazardous Substances Data)

Upstream product

• 706-06-9 3-(4-flurophenyl)prop-2-ynoic acid 
• 459-57-4 4-fluorobenzaldehyde 
• 766-98-3 1-ethynyl-4-fluorobenzene 
• 159957-00-3 1-(2,2-dibromovinyl)-4-fluorobenzene 

Downstream Products

• 934001-88-4 FCC₅H₄C₆H₁₁O₂C₃NOBr 
• 934001-98-6 FC₆H₄C₄H₃O₂NBr 
• 55606-94-5 1,4-bis(4'-fluorophenyl)-buta-1,3-diyne 
• 1379470-59-3 C₈H₅BrClF 
• 1429308-95-1 N-[2-(tert-butyldimethylsilyloxymethyl)allyl]-N-tert-butoxycarbonyl-(4-fluorophenyl)ethynylamine 
• 1638667-36-3 (Z)-5-(2-bromo-3-chloro-3-(4-fluorophenyl)allyl)dihydrofuran-2(3H)-one 

Relevant articles and documents

Palladium-Catalyzed Carbonylation in the Synthesis of N-Ynonylsulfoximines

Palladium-catalyzed carbonylation reactions with Cr(CO)6 as carbonyl source are key for the preparation of N-ynonylsulfoximines from NH-sulfoximines and bromoalkynes. The couplings proceed at room temperature with a wide range of substrate combinations affording the corresponding products in good yields. (Figure presented.).

Regio- and Stereoselective N-addition to an Open Bromo Vinyl Cation

A protocol for the synthesis of thus far inaccessible bromo vinyl triflimides is presented. Our previously reported concept of assisted vinyl cation formation was engaged to achieve both a protonation of relatively electron poor bromo alkynes and a reaction with high regio- and stereoselectivity. To the best of our knowledge, this is the first stereoselective addition of an N-nucleophile to an open β-halovinyl cation.

Fully Substituted Conjugate Benzofuran Core: Multiyne Cascade Coupling and Oxidation of Cyclopropenone

An unprecedented C═C double bond cleavage of cyclopropenone and dioxygen activation by multiyne cascade coupling has been developed. This chemistry provides a novel, simple, and efficient approach to synthesize fully substituted conjugate benzofuran derivatives from simple substrates under mild conditions. The density functional theory (DFT) calculations reveal that the unique homolytic cleavages of cyclopropenone and molecular oxygen are crucial to the success of this reaction.