2,6-Dimethyl-4-((2-(4-diphenylmethyl-1-piperazinyl)ethyl)amino)pyridine-2-carboxylic acid 3HCl

Base Information

Chemical Name:2,6-Dimethyl-4-((2-(4-diphenylmethyl-1-piperazinyl)ethyl)amino)pyridine-2-carboxylic acid 3HCl
CAS No.:110629-27-1
Molecular Formula:C27H32 N4 O2 . 3 Cl H
Molecular Weight:553.9514
Hs Code.:
DSSTox Substance ID:DTXSID60149343

Synonyms:2,6-Dimethyl-4-((2-(4-diphenylmethyl-1-piperazinyl)ethyl)amino)pyridine-2-carboxylic acid 3HCl;3-Pyridinecarboxylic acid, 2,6-dimethyl-4-((2-(4-(diphenylmethyl)-1-piperazinyl)ethyl)amino)-,hydrochloride, hydrate (1:3:2);110629-27-1;DTXSID60149343;C27H32N4O2.3ClH.2H2O;LS-130927;C27-H32-N4-O2.3Cl-H.2H2-O

Suppliers and Price of 2,6-Dimethyl-4-((2-(4-diphenylmethyl-1-piperazinyl)ethyl)amino)pyridine-2-carboxylic acid 3HCl

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2,6-Dimethyl-4-((2-(4-diphenylmethyl-1-piperazinyl)ethyl)amino)pyridine-2-carboxylic acid 3HCl

Chemical Property:

Vapor Pressure:2.19E-16mmHg at 25°C
Boiling Point:623.1°C at 760 mmHg
Flash Point:330.6°C
Hydrogen Bond Donor Count:5
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:8
Exact Mass:552.182559
Heavy Atom Count:36
Complexity:579

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC(=C(C(=N1)C)C(=O)O)NCCN2CCN(CC2)C(C3=CC=CC=C3)C4=CC=CC=C4.Cl.Cl.Cl

Technology Process of 2,6-Dimethyl-4-((2-(4-diphenylmethyl-1-piperazinyl)ethyl)amino)pyridine-2-carboxylic acid 3HCl

There total 5 articles about 2,6-Dimethyl-4-((2-(4-diphenylmethyl-1-piperazinyl)ethyl)amino)pyridine-2-carboxylic acid 3HCl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 110629-33-9
ethyl 2,6-dimethyl-4<(2-(4-diphenyl-methyl-1-piperazinyl)ethyl)amino>-pyridine-3-carboxylate

: 110629-27-1
2,6-dimethyl-4-<(2-(4-diphenylmethyl-1-piperazinyl)ethyl)amino>pyridine-3-carboxylic acid trihydrochloride dihydrate

Guidance literature:: With hydrogenchloride; potassium hydroxide; In ethylene glycol; at 170 ℃; for 2h;
DOI:10.1016/0223-5234(89)90003-2

Reference yield:

: 15513-48-1
4-chloro-2,6-dimethyl-3-nitropyridine

: 110629-27-1
2,6-dimethyl-4-<(2-(4-diphenylmethyl-1-piperazinyl)ethyl)amino>pyridine-3-carboxylic acid trihydrochloride dihydrate

Guidance literature:: Multi-step reaction with 4 steps

1: 93 percent / triethylamine / propan-2-ol / 20 h / Heating

2: 98 percent / thionylchloride / CH₂Cl₂ / 2 h / Heating

3: 45 percent / 1.) triethylamine; 2.) ethanolic HCl / dimethylformamide / 2 h / Heating

4: 65 percent / 1.) KOH; 2.) ethanolic HCl / ethane-1,2-diol / 2 h / 170 °C

With hydrogenchloride; potassium hydroxide; thionyl chloride; triethylamine; In dichloromethane; ethylene glycol; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1016/0223-5234(89)90003-2

Reference yield:

: 841-77-0
diphenylmethylpiperazine

: 110629-27-1
2,6-dimethyl-4-<(2-(4-diphenylmethyl-1-piperazinyl)ethyl)amino>pyridine-3-carboxylic acid trihydrochloride dihydrate

Guidance literature:: Multi-step reaction with 2 steps

1: 45 percent / 1.) triethylamine; 2.) ethanolic HCl / dimethylformamide / 2 h / Heating

2: 65 percent / 1.) KOH; 2.) ethanolic HCl / ethane-1,2-diol / 2 h / 170 °C

With hydrogenchloride; potassium hydroxide; triethylamine; In ethylene glycol; N,N-dimethyl-formamide;
DOI:10.1016/0223-5234(89)90003-2