methyl 4-crotonate

Base Information

Chemical Name:methyl 4-crotonate
CAS No.:165900-79-8
Molecular Formula:C₁₅H₁₉NO₄
Molecular Weight:277.32
Hs Code.:

methyl 4-<N-(4-ethoxycarbonylphenyl)-N-methylamino>crotonate

Synonyms:methyl 4-crotonate

Suppliers and Price of methyl 4-crotonate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl 4-crotonate

Chemical Property:

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Technology Process of methyl 4-crotonate

There total 1 articles about methyl 4-crotonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1117-71-1
methyl 4-bromocrotonate

: 10541-82-9
ethyl 4-(methylamino)benzoate

: 165900-79-8
methyl 4-crotonate

Guidance literature:: With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; potassium carbonate; at 80 ℃; for 13h;
DOI:10.1248/cpb.43.256

Reference yield: 99.0%

: 165900-79-8
methyl 4-crotonate

: 133719-37-6
methyl 4-butyrate

Guidance literature:: With hydrogen; acetic acid; nickel; In tetrahydrofuran; ethanol; for 0.5h;
DOI:10.1248/cpb.43.256

Reference yield:

: 165900-79-8
methyl 4-crotonate

: 133719-54-7
ethyl 4-pyrimidin-5-yl)ethyl>-N-methylamino>benzoate

Guidance literature:: Multi-step reaction with 5 steps

1: 99 percent / H₂, acetic acid / Raney Ni / ethanol; tetrahydrofuran / 0.5 h

2: 1.) LDA, 2.) I₂ / 1.) THF, -78 deg C, 30 min, 2.) THF, -78 deg C, 20 min

3: 1.) NaH, DMSO / 1.) 0 deg C, 5 min, 2.) DMSO, RT, 1.5 h

4: 74 percent / EtONa / ethanol; tetrahydrofuran / 3 h / Heating

5: 50 percent / BH₃*THF / tetrahydrofuran / 6 h / 0 °C

With borane-THF; hydrogen; iodine; sodium ethanolate; sodium hydride; acetic acid; dimethyl sulfoxide; lithium diisopropyl amide; nickel; In tetrahydrofuran; ethanol;
DOI:10.1248/cpb.43.256