1117-71-1Relevant articles and documents
Tethered aminohydroxylation: Synthesis of the β-amino acid of microsclerodermins A and B
Pullin, Robert D. C.,Rathi, Akshat H.,Melikhova, Ekaterina Y.,Winter, Christian,Thompson, Amber L.,Donohoe, Timothy J.
, p. 5492 - 5495 (2013)
The utility of the tethered aminohydroxylation (TA) has been demonstrated by synthesis of the complex β-amino acid residue of microsclerodermins A and B. The TA provided a regio- and stereoselective functionalization of a complex homoallylic alcohol. The route includes late-stage introduction of the aliphatic side chain via a cuprate addition and cross metathesis, a tactic designed to render the synthesis applicable to other microsclerodermins.
Electrochemical Conjugate Additions of the Allyl Groups in Substituted Allyl Halides to α,β-Unsaturated Esters
Satoh, Shohei,Suginome, Hiroshi,Tokuda, Masao
, p. 3456 - 3459 (1981)
Electrolysis of allyl halides and diethyl fumarate (2) in N,N-dimethylformamide containing 0.2 M tetraethylammonium tosylate gave a conjugate addition product, ethyl 3-(ethoxycarbonyl)-5-hexenoate, in a moderate yield.The electrochemical reaction of 1-chloro-3-methyl-2-butene (4) with 2, that of allyl chloride 4 with methyl crotonate (6), and that of methyl 4-halo-2-butenoate with 2 likewise gave the corresponding conjugate addition products, ethyl 3-(ethoxycarbonyl)-6-methyl-5-heptenoate, methyl 3,4,4-trimethyl-5-hexenoate, and ethyl 3-(ethoxycarbonyl)-4-(methoxycarbonyl)-5-hexenoate, respectively.The addition reaction of 4 to 2 takes place at the α-carbon terminus of 4 exclusively, whereas the addition of 4 to 6 at the γ-carbon terminus of 4 .These regioselectivities of the additions and pathways of the reactions are discussed.
The total synthesis of the oxopolyene macrolide RK-397
Mitton-Fry, Mark J.,Cullen, Aaron J.,Sammakia, Tarek
, p. 1066 - 1070 (2007)
It works both ways: The convergent total synthesis of the oxopolyene macrolide RK-397 utilizes remote asymmetric induction and a two-directional chain synthesis to prepare the polyol portion of the molecule, as well as a cross-metathesis reaction of a trienal with a terminal alkene to append the polyene to the polyol. (Chemical Equation Presented).
Chlorobenzene-pyridine compounds and application thereof
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Paragraph 0112; 0117; 0118; 0119, (2018/04/01)
The invention relates to chlorobenzene-pyridine compounds and an application thereof. The compounds can be used for preparing a Smoothened protein inhibitor and a drug for resisting adenocarcinoma andesophagus cancer and have the structure in the general formula (I) shown in the description, wherein X is selected from the structure shown in the description, R1 is selected from H or the structureshown in the description, and R2 is selected from the structure shown in the description.
Oxoindole spiro-compound based on allyl sulfide ylide serving as C3 synthon and synthesis method thereof
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Paragraph 0037-0039, (2017/12/06)
The invention relates to an oxoindole spiro-compound based on allyl sulfide ylide serving as a C3 synthon. The general chemical molecular formula is CHO, wherein m, n and x are respectively an integer of 1-10; the molecule has a structure as shown below in the specification; R is methyl, ethyl, acetyl, methylethyl ether, benzyl or di-tert-butyl dicarbonate; R is hydroxyl, methoxyl or ethoxyl; and R is 5-F, 5-Br, 5-Cl, 5-CH3, 5-OCH3, 6-Cl, 6-Br, 6-OCH3, 7-CH3, 7-Cl or 7-Br. The invention has the following advantages: through the characteristics of a tandem reaction, the method achieves the purpose of synthesizing the target product through one step, obviously improves the reaction efficiency, saves the reaction time and simplifies the reaction step, thereby providing a brand new method and idea for a trisubstituted five-element oxide spiro-compound, and providing a certain reference value for synthesis of similar compounds.
