N-ethyl-N-{4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl}-3-quinolinesulfonamide

Base Information

Chemical Name:N-ethyl-N-{4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl}-3-quinolinesulfonamide
CAS No.:1351184-59-2
Molecular Formula:C₂₆H₃₄N₄O₃S
Molecular Weight:482.647
Hs Code.:

Synonyms:N-ethyl-N-{4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl}-3-quinolinesulfonamide

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Chemical Property of N-ethyl-N-{4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl}-3-quinolinesulfonamide

Chemical Property:

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Technology Process of N-ethyl-N-{4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl}-3-quinolinesulfonamide

There total 3 articles about N-ethyl-N-{4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl}-3-quinolinesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1350978-15-2
N-ethyl-N-(4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl)amine

: 159182-40-8
quinoline-3-sulfonyl chloride

: 1351184-59-2
N-ethyl-N-{4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl}-3-quinolinesulfonamide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃;
DOI:10.1016/j.bmc.2011.09.044

Reference yield:

: 263017-66-9
N-(4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl)acetamide

: 1351184-59-2
N-ethyl-N-{4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl}-3-quinolinesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / Inert atmosphere; Reflux

2: triethylamine / dichloromethane / 20 °C

With lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmc.2011.09.044

Reference yield:

: 21103-33-3
4-[4-(2-methoxyphenyl)piperazin-1-yl]butylamine

: 1351184-59-2
N-ethyl-N-{4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl}-3-quinolinesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydrogencarbonate / dichloromethane; water / 6 h / 20 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / Inert atmosphere; Reflux

3: triethylamine / dichloromethane / 20 °C

With lithium aluminium tetrahydride; sodium hydrogencarbonate; triethylamine; In tetrahydrofuran; dichloromethane; water;
DOI:10.1016/j.bmc.2011.09.044