21103-33-3

Basic information

• Product Name: 4-[4-(2-METHOXY-PHENYL)-PIPERAZIN-1-YL]-BUTYLAMINE
• Synonyms: 4-[4-(2-METHOXY-PHENYL)-PIPERAZIN-1-YL]-BUTYLAMINE;1-(4-aMino-1-butyl)-4-(2-Methoxyphenyl)piperazine;1-(4-Aminobutyl)-4-(2-methoxyphenyl)piperazine;4-[4-(2-Methoxyphenyl)-1-piperazinyl]butylamine
• CAS NO: 21103-33-3
• Molecular Formula: C₁₅H₂₅N₃O
• Molecular Weight: 263.3785
• Mol File: 21103-33-3.mol
• Article Data: 39

Chemical Properties

• Boiling Point: 405.501°C at 760 mmHg
• Flash Point: 199.04°C
• Appearance: /
• Density: 1.049g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.541
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-[4-(2-METHOXY-PHENYL)-PIPERAZIN-1-YL]-BUTYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[4-(2-METHOXY-PHENYL)-PIPERAZIN-1-YL]-BUTYLAMINE(21103-33-3)
• EPA Substance Registry System: 4-[4-(2-METHOXY-PHENYL)-PIPERAZIN-1-YL]-BUTYLAMINE(21103-33-3)

Safety Data

• Hazard Codes: C
• Statements: 34-52
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 2735PSN1 8 / PGII
• Hazardous Substances Data: 21103-33-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C15H25N3O/c1-19-15-7-3-2-6-14(15)18-12-10-17(11-13-18)9-5-4-8-16/h2-3,6-7H,4-5,8-13,16H2,1H3

Upstream product

• 1221408-65-6 4-(4-(2-methoxyphenyl)piperazin-1-yl)butan-1-amine hydrochloride 
• 5394-18-3 2-(4-bromobutyl)isoindoline-1,3-dione 
• 35386-24-4 1-(2-Methoxyphenyl)piperazine 
• 5464-78-8 1-(2-methoxyphenyl)piperazine hydrochloride 
• 25024-99-1 4‐[4‐(2‐methoxyphenyl)piperazin‐1‐yl]butannitrile 
• 102392-05-2 2-(4-(4-(2-methoxyphenyl)-piperazin-1-yl)butyl)-isoindole-1,3-dione 

Downstream Products

• 134390-72-0 4-[4-(1-adamantanecarboxamido)butyl]-1-(2-methoxyphenyl)piperazine 
• 134390-69-5 Pentanoic acid {4-[4-(2-methoxy-phenyl)-piperazin-1-yl]-butyl}-amide 
• 744213-73-8 5-bromo-thiophene-2-carboxylic acid {4-[4-(2-methoxy-phenyl)-piperazin-1-yl]-butyl}-amide 
• 644988-82-9 5-bromo-benzofuran-2-carboxylic acid {4-[4-(2-methoxy-phenyl)-piperazin-1-yl]-butyl}-amide 
• 644988-72-7 5-bromo-benzo[b]thiophene-2-carboxylic acid {4-[4-(2-methoxy-phenyl)-piperazin-1-yl]-butyl}-amide 

Relevant articles and documents

Preparation, characterization, and screening of a high affinity organometallic probe for α-adrenergic receptors

Figure Presented. An organometallic rhenium complex having high and selective affinity for α-adrenergic receptors is reported. A series of methoxyphenylpiperazinecarborane ligands complexed to the [Re(CO) 3]+ core were prepared and t

Synthesis, in silico, and in vitro studies of novel dopamine D2 and D3 receptor ligands

Dopamine is an important neurotransmitter in the human brain and its altered concentrations can lead to various neurological diseases. We studied the binding of novel compounds at the dopamine D2 (D2R) and D3 (D3/sub

Benzyl Phenylsemicarbazides: A Chemistry-Driven Approach Leading to G Protein-Biased Dopamine D4 Receptor Agonists with High Subtype Selectivity

Many subtype-selective dopamine receptor ligands developed for the D2-D4 family incorporate a 1-arylpiperazine-derived primary recognition motif, which is connected to a lipophilic moiety occupying an extended binding pocket (EBP) of the receptor via an aliphatic linker of variable lengths. The evaluation of a novel group of dopamine receptor ligands now showed that highly subtype-selective ligands [up to Ki(D4.4) = 0.25 nM, D2L/D4.4 = 320, D3/D4.4 = 710 for APH199 (17)] can be obtained by choosing a relatively large and conformationally flexible 1-benzyl-1-phenylsemicarbazide substructure to fill the EBP. The novel chemotype APH199 (17) was found to act as a full agonist at the D4 receptor showing significant bias toward G protein activation over β-arrestin recruitment in comparison to quinpirole.