N-[3-(pyridine-3-sulfonyl)-5-(1-triisopropylsilanyl-1H-indol-4-yl)-phenyl]-acetamide

Base Information

Chemical Name:N-[3-(pyridine-3-sulfonyl)-5-(1-triisopropylsilanyl-1H-indol-4-yl)-phenyl]-acetamide
CAS No.:915413-24-0
Molecular Formula:C₃₀H₃₇N₃O₃SSi
Molecular Weight:547.794
Hs Code.:

Synonyms:N-[3-(pyridine-3-sulfonyl)-5-(1-triisopropylsilanyl-1H-indol-4-yl)-phenyl]-acetamide

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Chemical Property of N-[3-(pyridine-3-sulfonyl)-5-(1-triisopropylsilanyl-1H-indol-4-yl)-phenyl]-acetamide

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Technology Process of N-[3-(pyridine-3-sulfonyl)-5-(1-triisopropylsilanyl-1H-indol-4-yl)-phenyl]-acetamide

There total 5 articles about N-[3-(pyridine-3-sulfonyl)-5-(1-triisopropylsilanyl-1H-indol-4-yl)-phenyl]-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 915413-23-9
N-[3-chloro-5-(pyridine-3-sulfonyl)-phenyl]-acetamide

: 690632-17-8
4-(4,4,5,5-tetramethyl-1,3,2-dioxoborolan-2-yl)-1-(triisopropylsilyl)-1H-indole

: 915413-24-0
N-[3-(pyridine-3-sulfonyl)-5-(1-triisopropylsilanyl-1H-indol-4-yl)-phenyl]-acetamide

Guidance literature:: With chloro(di-2-norbornylphosphino)(2'-dimethylamino-1,1'-biphenyl-2-yl)palladium(II); potassium carbonate; In 1,4-dioxane; at 120 ℃; for 1h; Microwave irradiation; Inert atmosphere;
DOI:10.1016/j.tetlet.2011.01.140

Reference yield:

: 1120-90-7
3-iodopyridine

: 915413-24-0
N-[3-(pyridine-3-sulfonyl)-5-(1-triisopropylsilanyl-1H-indol-4-yl)-phenyl]-acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium tert-butylate; bis[2-(diphenylphosphino)phenyl] ether / toluene

2: sodium tungstate; dihydrogen peroxide

3: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 1 h / 120 °C / Microwave irradiation; Inert atmosphere

4: chloro(di-2-norbornylphosphino)(2'-dimethylamino-1,1'-biphenyl-2-yl)palladium(II); potassium carbonate / 1,4-dioxane / 1 h / 120 °C / Microwave irradiation; Inert atmosphere

With sodium tungstate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; chloro(di-2-norbornylphosphino)(2'-dimethylamino-1,1'-biphenyl-2-yl)palladium(II); potassium tert-butylate; dihydrogen peroxide; potassium carbonate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; bis[2-(diphenylphosphino)phenyl] ether; In 1,4-dioxane; toluene; 3: Buchwald type coupling reaction / 4: Suzuki reaction;
DOI:10.1016/j.tetlet.2011.01.140

Reference yield:

: 915413-21-7
3-(3,5-dichloro-phenylsulfanyl)-pyridine

: 915413-24-0
N-[3-(pyridine-3-sulfonyl)-5-(1-triisopropylsilanyl-1H-indol-4-yl)-phenyl]-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium tungstate; dihydrogen peroxide

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene / 1,4-dioxane / 1 h / 120 °C / Microwave irradiation; Inert atmosphere

3: chloro(di-2-norbornylphosphino)(2'-dimethylamino-1,1'-biphenyl-2-yl)palladium(II); potassium carbonate / 1,4-dioxane / 1 h / 120 °C / Microwave irradiation; Inert atmosphere

With sodium tungstate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; chloro(di-2-norbornylphosphino)(2'-dimethylamino-1,1'-biphenyl-2-yl)palladium(II); dihydrogen peroxide; potassium carbonate; caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; In 1,4-dioxane; 2: Buchwald type coupling reaction / 3: Suzuki reaction;
DOI:10.1016/j.tetlet.2011.01.140