2-{p-[3-(2-ethoxyethyl)amino-2-hydroxypropoxy]phenyl}-4-(thien-2-yl)imidazole

Base Information

Chemical Name:2-{p-[3-(2-ethoxyethyl)amino-2-hydroxypropoxy]phenyl}-4-(thien-2-yl)imidazole
CAS No.:126007-80-5
Molecular Formula:C₂₀H₂₅N₃O₃S
Molecular Weight:387.503
Hs Code.:

Synonyms:2-{p-[3-(2-ethoxyethyl)amino-2-hydroxypropoxy]phenyl}-4-(thien-2-yl)imidazole

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Chemical Property of 2-{p-[3-(2-ethoxyethyl)amino-2-hydroxypropoxy]phenyl}-4-(thien-2-yl)imidazole

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Technology Process of 2-{p-[3-(2-ethoxyethyl)amino-2-hydroxypropoxy]phenyl}-4-(thien-2-yl)imidazole

There total 5 articles about 2-{p-[3-(2-ethoxyethyl)amino-2-hydroxypropoxy]phenyl}-4-(thien-2-yl)imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-(p-hydroxyphenyl)-4-(thien-2-yl)imidazole

: 126007-94-1
2-Phenyl-3-(2-ethoxyethyl)-5-(hydroxymethyl)-oxazolidine

: 7732-18-5
water

: 497-19-8
sodium carbonate

: 126007-80-5
2-{p-[3-(2-ethoxyethyl)amino-2-hydroxypropoxy]phenyl}-4-(thien-2-yl)imidazole

Guidance literature:: With ammonia; acetic acid; In pyridine; N,N-dimethyl-formamide; p-toluenesulfonyl chloride;

Reference yield:

: 3-(2-Ethoxy-ethyl)-2-phenyl-5-[4-(5-thiophen-2-yl-1H-imidazol-2-yl)-phenoxymethyl]-oxazolidine

: 126007-80-5
2-<4-<3-<(2-ethoxyethyl)amino>-2-hydroxypropoxy>phenyl>-4-(2-thienyl)imidazole

Guidance literature:: With water; acetic acid; for 18h; Yield given; Ambient temperature;
DOI:10.1021/jm00156a028

Reference yield:

: 102151-79-1
Toluene-4-sulfonic acid 3-(2-ethoxy-ethyl)-2-phenyl-oxazolidin-5-ylmethyl ester

: 126007-80-5
2-<4-<3-<(2-ethoxyethyl)amino>-2-hydroxypropoxy>phenyl>-4-(2-thienyl)imidazole

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) NaH / 1.) DMF, 70 deg C, 15 min, 2.) DMF, 120 deg C, 18 h

2: H₂O, AcOH / 18 h / Ambient temperature

With water; sodium hydride; acetic acid;
DOI:10.1021/jm00156a028