tert-butyl [(1R,3R,5S)-3-(3-aminopyridin-4-yl)-5-(trifluoromethyl)cyclohexyl]carbamate

Base Information

Chemical Name:tert-butyl [(1R,3R,5S)-3-(3-aminopyridin-4-yl)-5-(trifluoromethyl)cyclohexyl]carbamate
CAS No.:1210418-44-2
Molecular Formula:C₁₇H₂₄F₃N₃O₂
Molecular Weight:359.392
Hs Code.:

Synonyms:tert-butyl [(1R,3R,5S)-3-(3-aminopyridin-4-yl)-5-(trifluoromethyl)cyclohexyl]carbamate

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Chemical Property of tert-butyl [(1R,3R,5S)-3-(3-aminopyridin-4-yl)-5-(trifluoromethyl)cyclohexyl]carbamate

Chemical Property:

Purity/Quality:

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Technology Process of tert-butyl [(1R,3R,5S)-3-(3-aminopyridin-4-yl)-5-(trifluoromethyl)cyclohexyl]carbamate

There total 9 articles about tert-butyl [(1R,3R,5S)-3-(3-aminopyridin-4-yl)-5-(trifluoromethyl)cyclohexyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: rac-4-[(3S,5S)-3-azido-5-(trifluoromethyl)cyclohex-1-en-1-yl]-3-nitropyridine

: tert-butyl [(1S,3S,5R)-3-(3-aminopyridin-4-yl)-5-(trifluoromethyl)cyclohexyl]carbamate

: 1210418-44-2
tert-butyl [(1R,3R,5S)-3-(3-aminopyridin-4-yl)-5-(trifluoromethyl)cyclohexyl]carbamate

: tert-butyl rac-[(1S,3R,5R)-3-(3-aminopyridin-4-yl)-5-(trifluoromethyl)cyclohexyl]carbamate

Guidance literature:: With 20% palladium hydroxide-activated charcoal; hydrogen; In methanol; under 760.051 Torr; Inert atmosphere;

Reference yield:

: tert-butyl cis-3-(3-aminopyridin-4-yl)-5-(trifluoromethyl)cyclohexylcarbamate

: tert-butyl [(1S,3S,5R)-3-(3-aminopyridin-4-yl)-5-(trifluoromethyl)cyclohexyl]carbamate

: 1210418-44-2
tert-butyl [(1R,3R,5S)-3-(3-aminopyridin-4-yl)-5-(trifluoromethyl)cyclohexyl]carbamate

Guidance literature:: With Chiralcel IC; In n-heptane; isopropyl alcohol; Resolution of racemate;

Reference yield:

: 124612-15-3
5-(trifluoromethyl)-cyclohexane-1,3-dione

: tert-butyl [(1S,3S,5R)-3-(3-aminopyridin-4-yl)-5-(trifluoromethyl)cyclohexyl]carbamate

: 1210418-44-2
tert-butyl [(1R,3R,5S)-3-(3-aminopyridin-4-yl)-5-(trifluoromethyl)cyclohexyl]carbamate

Guidance literature:: Multi-step reaction with 7 steps

1: triethylamine / dichloromethane / 2 h / 0 °C

2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / 1,4-dioxane / 2 h / 80 °C / Inert atmosphere

3: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / 1,4-dioxane / 2 h / Inert atmosphere; Heating

4: ethanol; sodium tetrahydroborate; cerium(III) chloride heptahydrate / 1 h / 0 °C

5: triethylamine / dichloromethane / 0 - 30 °C

6: sodium azide / N,N-dimethyl-formamide / 20 - 30 °C

7: hydrogen; 20% palladium hydroxide-activated charcoal / methanol / 760.05 Torr / Inert atmosphere

With sodium tetrahydroborate; sodium azide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; ethanol; cerium(III) chloride heptahydrate; 20% palladium hydroxide-activated charcoal; hydrogen; potassium acetate; sodium carbonate; triethylamine; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; 2: |Suzuki Coupling / 3: |Suzuki Coupling;