2-(p-Chlorophenyl)-2-hydroxyacetamide

Base Information

• Chemical Name: 2-(p-Chlorophenyl)-2-hydroxyacetamide
• CAS No.: 18584-27-5
• Molecular Formula: C8H8ClNO2
• Molecular Weight: 185.61
• Hs Code.: 2924299090
• Mol file: 18584-27-5.mol

Synonyms:4-Chlor-mandelsaeure-amid;4-Chlor-DL-mandelamid;4-chloro-mandelic acid-amide;Mandelamide,p-chloro;

Chemical Property of 2-(p-Chlorophenyl)-2-hydroxyacetamide

Chemical Property:

• Vapor Pressure: 1.4E-06mmHg at 25°C
• Boiling Point: 383.9°C at 760 mmHg
• Flash Point: 186°C
• PSA: 63.32000
• Density: 1.392g/cm³
• LogP: 1.55900

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(p-Chlorophenyl)-2-hydroxyacetamide

There total 6 articles about 2-(p-Chlorophenyl)-2-hydroxyacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methyl 4-chloromandelate (32174-34-8,63096-36-6,104420-79-3,13305-19-6) → 2-(4-chlorophenyl)-2-hydroxyacetamide (18584-27-5)

Guidance literature:

With ammonia; In methanol; Cooling with ice;

DOI:10.1246/cl.161006

Reference yield: 70.0%

4-chloromandelonitrile (13312-83-9) → 2-(4-chlorophenyl)-2-hydroxyacetamide (18584-27-5)

Guidance literature:

With C₃₄H₃₈N₆NiO₂⁽²⁺⁾*2Cl^(1-); water; In isopropyl alcohol; at 100 ℃; for 48h; Schlenk technique; Inert atmosphere;

DOI:10.1002/chem.201700816

Reference yield:

p-chloromandelic acid (7138-34-3,32189-36-9,76496-63-4,492-86-4) → 2-(4-chlorophenyl)-2-hydroxyacetamide (18584-27-5)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid

2: ethanol; diethyl ether; ammonia

With diethyl ether; ethanol; sulfuric acid; ammonia;

DOI:10.1021/ja01357a045

upstream raw materials:

methyl 4-chloromandelate

4-chloro-mandelimidic acid ethyl ester

water

p-chloromandelic acid

Downstream raw materials:

2-(4-chlorophenyl)-2-hydroxy-1-phenylethanone

2-(4-chlorophenyl)-2-hydroxy-N-phenylacetamide