Ethanone, 2-(4-chlorophenyl)-2-hydroxy-1-phenyl-

Base Information

• Chemical Name: Ethanone, 2-(4-chlorophenyl)-2-hydroxy-1-phenyl-
• CAS No.: 71292-81-4
• Molecular Formula: C14H11ClO2
• Molecular Weight: 246.693
• DSSTox Substance ID: DTXSID50458411
• Nikkaji Number: J536.379I
• Mol file: 71292-81-4.mol

Synonyms:4'-chlorobenzoin;Ethanone, 2-(4-chlorophenyl)-2-hydroxy-1-phenyl-;71292-81-4;SCHEMBL142537;DTXSID50458411

Chemical Property of Ethanone, 2-(4-chlorophenyl)-2-hydroxy-1-phenyl-

Chemical Property:

• XLogP3: 2.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 246.0447573
• Heavy Atom Count: 17
• Complexity: 253

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C(=O)C(C2=CC=C(C=C2)Cl)O

Technology Process of Ethanone, 2-(4-chlorophenyl)-2-hydroxy-1-phenyl-

There total 25 articles about Ethanone, 2-(4-chlorophenyl)-2-hydroxy-1-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(4-chlorophenyl)(2-phenyl-1,3-dithian-2-yl)methanol (1333394-45-8) → 2-(4-chlorophenyl)-2-hydroxy-1-phenylethanone (71292-81-4)

Guidance literature:

With boron trifluoride diethyl etherate; mercury(II) oxide; In tetrahydrofuran; water; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1016/j.tet.2011.07.030

Reference yield: 81.0%

benzoyltrimethylsilane (5908-41-8) + 4-chlorobenzaldehyde (104-88-1) → 2-(4-chlorophenyl)-2-hydroxy-1-phenylethanone (71292-81-4)

Guidance literature:

In dichloromethane; at 20 ℃; for 20h; Inert atmosphere; Irradiation; Schlenk technique;

DOI:10.1002/adsc.202100186

Reference yield: 72.0%

diethyl α-trimethylsilyloxy-α-(4-chlorobenzoyl)benzylphosphonate (71292-76-7) → 4-chlorobenzil (22711-23-5) + 2-(4-chlorophenyl)-2-hydroxy-1-phenylethanone (71292-81-4)

Guidance literature:

With sodium hydroxide; In ethanol; for 0.0833333h; Ambient temperature;

DOI:10.1246/bcsj.55.218

upstream raw materials:

ethanol

2-bromo-2-(4-chlorophenyl)-1-phenylethanone

sodium ethanolate

4-chloromandelonitrile

Downstream raw materials:

5-(4-chloro-phenyl)-4-phenyl-3H-oxazol-2-one

4-chlorobenzil

(S)-1-(4-chlorophenyl)-2-oxo-2-phenylethyl butyrate

4⁽⁵⁾-(4-chlorophenyl)-2,3-dihydro-5⁽⁴⁾-phenyl-1H-imidazole-2-thione