5-Hydroxy-2-(4-aminophenyl)benzofuran

Base Information

Chemical Name:5-Hydroxy-2-(4-aminophenyl)benzofuran
CAS No.:888703-99-9
Molecular Formula:C₁₄H₁₁NO₂
Molecular Weight:225.247
Hs Code.:
ChEMBL ID:CHEMBL380476
DSSTox Substance ID:DTXSID201301227
Pharos Ligand ID:JFLHJY7W6CMF

Synonyms:CHEMBL380476;5-hydroxy-2-(4-aminophenyl)benzofuran;888703-99-9;DTXSID201301227;2-(4-Aminophenyl)-5-benzofuranol;BDBM50185949;AKOS015966000;PD182597

Suppliers and Price of 5-Hydroxy-2-(4-aminophenyl)benzofuran

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-Hydroxy-2-(4-aminophenyl)benzofuran

Chemical Property:

XLogP3:3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:225.078978594
Heavy Atom Count:17
Complexity:263

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC(=CC=C1C2=CC3=C(O2)C=CC(=C3)O)N

Technology Process of 5-Hydroxy-2-(4-aminophenyl)benzofuran

There total 5 articles about 5-Hydroxy-2-(4-aminophenyl)benzofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.5%

: 888703-98-8
2-(4'-aminophenyl)-5-methoxybenzo[b]furan

: 888703-99-9
2-(4-amino-phenyl)-benzofuran-5-ol

Guidance literature:: With boron tribromide; In dichloromethane; at 20 ℃; for 0.5h;
DOI:10.1021/jm051176k

Reference yield:

: 888703-97-7
2-(4'-nitrophenyl)-5-methoxybenzo[b]furan

: 888703-99-9
2-(4-amino-phenyl)-benzofuran-5-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 92.9 percent / SnCl₂ / ethanol / 2 h / Heating

2: 10.5 percent / BBr₃ / CH₂Cl₂ / 0.5 h / 20 °C

With boron tribromide; tin(ll) chloride; In ethanol; dichloromethane;
DOI:10.1021/jm051176k

Reference yield:

: 672-13-9
2-hydroxy-5-methoxybenzaldehyde

: 888703-99-9
2-(4-amino-phenyl)-benzofuran-5-ol

Guidance literature:: Multi-step reaction with 5 steps

1: 99.7 percent / NaBH₄ / ethanol / 1 h / 20 °C

2: 84.1 percent / acetonitrile / 1 h / Heating

3: 32.9 percent / triethylamine / toluene / 2 h / Heating

4: 92.9 percent / SnCl₂ / ethanol / 2 h / Heating

5: 10.5 percent / BBr₃ / CH₂Cl₂ / 0.5 h / 20 °C

With sodium tetrahydroborate; boron tribromide; triethylamine; tin(ll) chloride; In ethanol; dichloromethane; toluene; acetonitrile; 3: intramolecular Wittig reaction;
DOI:10.1021/jm051176k