3-(4-methoxymethoxy-3-{2-methoxy-4-[3-(2-methoxymethoxy-phenyl)-3-oxo-propyl]-phenoxy}-phenyl)-1-(2-methoxymethoxy-phenyl)-propan-1-one

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Chemical Name:3-(4-methoxymethoxy-3-{2-methoxy-4-[3-(2-methoxymethoxy-phenyl)-3-oxo-propyl]-phenoxy}-phenyl)-1-(2-methoxymethoxy-phenyl)-propan-1-one
CAS No.:886054-90-6
Molecular Formula:C₃₇H₄₀O₁₀
Molecular Weight:644.719
Hs Code.:

Synonyms:3-(4-methoxymethoxy-3-{2-methoxy-4-[3-(2-methoxymethoxy-phenyl)-3-oxo-propyl]-phenoxy}-phenyl)-1-(2-methoxymethoxy-phenyl)-propan-1-one

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Chemical Property of 3-(4-methoxymethoxy-3-{2-methoxy-4-[3-(2-methoxymethoxy-phenyl)-3-oxo-propyl]-phenoxy}-phenyl)-1-(2-methoxymethoxy-phenyl)-propan-1-one

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Technology Process of 3-(4-methoxymethoxy-3-{2-methoxy-4-[3-(2-methoxymethoxy-phenyl)-3-oxo-propyl]-phenoxy}-phenyl)-1-(2-methoxymethoxy-phenyl)-propan-1-one

There total 13 articles about 3-(4-methoxymethoxy-3-{2-methoxy-4-[3-(2-methoxymethoxy-phenyl)-3-oxo-propyl]-phenoxy}-phenyl)-1-(2-methoxymethoxy-phenyl)-propan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 68314-54-5
1-bromo-2-(methoxymethoxy)benzene

: 704912-97-0
N-methoxy-3-[3-methoxy-4-[2-(methoxymethoxy)-5-(2-(N-methoxy-N-methylcarbamoyl)ethyl)phenoxy]phenyl]-N-methylpropanamide

: 886054-90-6
3-(4-methoxymethoxy-3-{2-methoxy-4-[3-(2-methoxymethoxy-phenyl)-3-oxo-propyl]-phenoxy}-phenyl)-1-(2-methoxymethoxy-phenyl)-propan-1-one

Guidance literature:: 1-bromo-2-(methoxymethoxy)benzene; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃;

N-methoxy-3-[3-methoxy-4-[2-(methoxymethoxy)-5-(2-(N-methoxy-N-methylcarbamoyl)ethyl)phenoxy]phenyl]-N-methylpropanamide; In tetrahydrofuran; hexane; for 0.5h;
DOI:10.1016/j.bmc.2005.11.055

Reference yield:

: 704912-87-8
3-(5-bromo-3-chloro-4-hydroxyphenyl)propyl acetate

: 886054-90-6
3-(4-methoxymethoxy-3-{2-methoxy-4-[3-(2-methoxymethoxy-phenyl)-3-oxo-propyl]-phenoxy}-phenyl)-1-(2-methoxymethoxy-phenyl)-propan-1-one

Guidance literature:: Multi-step reaction with 13 steps

1.1: 50 percent / LiClO₄ / Electrochemical reaction

2.1: 70 percent / Zn; AcOH / tetrahydrofuran / 0 °C

3.1: 100 percent / DIPEA / CH₂Cl₂

4.1: 100 percent / K₂CO₃; MeOH / 20 °C

5.1: 100 percent / imidazole / dimethylformamide / 6 h

6.1: n-BuLi / tetrahydrofuran; hexane / 0.05 h / -78 °C

6.2: B(OMe)3 / tetrahydrofuran; hexane / 2 h

6.3: 64 percent / H₂O₂; NaOH / tetrahydrofuran; hexane; H₂O / 0 °C

7.1: 100 percent / K₂CO₃ / dimethylformamide

8.1: 84 percent / HCO₂NH₄ / Pd/C / ethanol / 3 h / 60 °C

9.1: 100 percent / TBAF / tetrahydrofuran

10.1: 81 percent / Dess-Martin periodinane; pyridine / CH₂Cl₂ / 2 h / 20 °C

11.1: 52 percent / PDC / dimethylformamide / 20 °C

12.1: 96 percent / Et₃N; HOBt; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide / CH₂Cl₂ / 20 °C

13.1: n-BuLi / tetrahydrofuran; hexane / -78 °C

13.2: 67 percent / tetrahydrofuran; hexane / 0.5 h

With pyridine; 1H-imidazole; methanol; dipyridinium dichromate; n-butyllithium; tetrabutyl ammonium fluoride; ammonium formate; lithium perchlorate; potassium carbonate; benzotriazol-1-ol; Dess-Martin periodane; acetic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; N-ethyl-N,N-diisopropylamine; zinc; palladium on activated charcoal; In tetrahydrofuran; ethanol; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2005.11.055

Reference yield:

: 704912-91-4
3-[5-(4-(3-acetyloxypropyl)-2-bromo-6-chlorophenoxy)-3-chloro-4-hydroxyphenyl]propyl acetate

: 886054-90-6
3-(4-methoxymethoxy-3-{2-methoxy-4-[3-(2-methoxymethoxy-phenyl)-3-oxo-propyl]-phenoxy}-phenyl)-1-(2-methoxymethoxy-phenyl)-propan-1-one

Guidance literature:: Multi-step reaction with 11 steps

1.1: 100 percent / DIPEA / CH₂Cl₂

2.1: 100 percent / K₂CO₃; MeOH / 20 °C

3.1: 100 percent / imidazole / dimethylformamide / 6 h

4.1: n-BuLi / tetrahydrofuran; hexane / 0.05 h / -78 °C

4.2: B(OMe)3 / tetrahydrofuran; hexane / 2 h

4.3: 64 percent / H₂O₂; NaOH / tetrahydrofuran; hexane; H₂O / 0 °C

5.1: 100 percent / K₂CO₃ / dimethylformamide

6.1: 84 percent / HCO₂NH₄ / Pd/C / ethanol / 3 h / 60 °C

7.1: 100 percent / TBAF / tetrahydrofuran

8.1: 81 percent / Dess-Martin periodinane; pyridine / CH₂Cl₂ / 2 h / 20 °C

9.1: 52 percent / PDC / dimethylformamide / 20 °C

10.1: 96 percent / Et₃N; HOBt; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide / CH₂Cl₂ / 20 °C

11.1: n-BuLi / tetrahydrofuran; hexane / -78 °C

11.2: 67 percent / tetrahydrofuran; hexane / 0.5 h

With pyridine; 1H-imidazole; methanol; dipyridinium dichromate; n-butyllithium; tetrabutyl ammonium fluoride; ammonium formate; potassium carbonate; benzotriazol-1-ol; Dess-Martin periodane; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2005.11.055