3-(5-bromo-3-chloro-4-hydroxyphenyl)propyl acetate

Base Information

• Chemical Name: 3-(5-bromo-3-chloro-4-hydroxyphenyl)propyl acetate
• CAS No.: 704912-87-8
• Molecular Formula: C₁₁H₁₂BrClO₃
• Molecular Weight: 307.571
• Mol file: 704912-87-8.mol

Synonyms:3-(5-bromo-3-chloro-4-hydroxyphenyl)propyl acetate

Chemical Property of 3-(5-bromo-3-chloro-4-hydroxyphenyl)propyl acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(5-bromo-3-chloro-4-hydroxyphenyl)propyl acetate

There total 2 articles about 3-(5-bromo-3-chloro-4-hydroxyphenyl)propyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

acetic acid 3-(3-chloro-4-hydroxy-phenyl)-propyl ester (704912-98-1) → 3-(5-bromo-3-chloro-4-hydroxyphenyl)propyl acetate (704912-87-8)

Guidance literature:

With pyridine; pyridinium perbromide hydrobromide; In chloroform; at 0 ℃; for 3h;

DOI:10.1016/j.bmc.2005.11.055

Reference yield:

3-(4'-hydroxyphenyl)-1-propyl acetate (80373-18-8) → 3-(5-bromo-3-chloro-4-hydroxyphenyl)propyl acetate (704912-87-8)

Guidance literature:

3-(4'-hydroxyphenyl)-1-propyl acetate; With sulfuryl dichloride; In chloroform;

With pyridinium hydrobromide perbromide; Further stages.;

DOI:10.1016/j.tetlet.2004.02.154

Reference yield:

3-(5-bromo-3-chloro-4-hydroxyphenyl)propyl acetate (704912-87-8) → 3-[3-methoxy-4-(2-(methoxymethoxy)-5-(3-oxopropyl)phenoxy)phenyl]propanal (704912-94-7)

Guidance literature:

Multi-step reaction with 10 steps

1.1: 50 percent / LiClO₄ / Electrochemical reaction

2.1: 70 percent / Zn; AcOH / tetrahydrofuran / 0 °C

3.1: 100 percent / DIPEA / CH₂Cl₂

4.1: 100 percent / K₂CO₃; MeOH / 20 °C

5.1: 100 percent / imidazole / dimethylformamide / 6 h

6.1: n-BuLi / tetrahydrofuran; hexane / 0.05 h / -78 °C

6.2: B(OMe)3 / tetrahydrofuran; hexane / 2 h

6.3: 64 percent / H₂O₂; NaOH / tetrahydrofuran; hexane; H₂O / 0 °C

7.1: 100 percent / K₂CO₃ / dimethylformamide

8.1: 84 percent / HCO₂NH₄ / Pd/C / ethanol / 3 h / 60 °C

9.1: 100 percent / TBAF / tetrahydrofuran

10.1: 81 percent / Dess-Martin periodinane; pyridine / CH₂Cl₂ / 2 h / 20 °C

With pyridine; 1H-imidazole; methanol; n-butyllithium; tetrabutyl ammonium fluoride; ammonium formate; lithium perchlorate; potassium carbonate; Dess-Martin periodane; acetic acid; N-ethyl-N,N-diisopropylamine; zinc; palladium on activated charcoal; In tetrahydrofuran; ethanol; hexane; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2005.11.055

upstream raw materials:

3-(4'-hydroxyphenyl)-1-propyl acetate

acetic acid 3-(3-chloro-4-hydroxy-phenyl)-propyl ester

Downstream raw materials:

3-[3-(4-(3-acetyloxypropyl)-2-bromo-6-chlorophenoxy)-5-chloro-1-methoxy-4-oxocyclohexa-2,5-dienyl]propyl acetate

3-[4-(2-(methoxymethoxy)-5-(3-oxopropyl)phenoxy)-phenyl]propanal

3-{3-[4-(3-hydroxy-propyl)-phenoxy]-4-methoxymethoxy-phenyl}-propan-1-ol

3-[4-(5-(2-carboxyethyl)-2-(methoxymethoxy)phenoxy)phenyl]propionic acid