bis[8-[(tetrahydro-2H-pyran-2-yl)oxy]octyl] 5-nitroisophthalate

Base Information

• Chemical Name: bis[8-[(tetrahydro-2H-pyran-2-yl)oxy]octyl] 5-nitroisophthalate
• CAS No.: 406206-21-1
• Molecular Formula: C₃₄H₅₃NO₁₀
• Molecular Weight: 635.796
• Mol file: 406206-21-1.mol

Synonyms:bis[8-[(tetrahydro-2H-pyran-2-yl)oxy]octyl] 5-nitroisophthalate

Chemical Property of bis[8-[(tetrahydro-2H-pyran-2-yl)oxy]octyl] 5-nitroisophthalate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of bis[8-[(tetrahydro-2H-pyran-2-yl)oxy]octyl] 5-nitroisophthalate

There total 1 articles about bis[8-[(tetrahydro-2H-pyran-2-yl)oxy]octyl] 5-nitroisophthalate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

8-(tetrahydro-2H-pyran-2-yloxy)octan-1-ol (51326-52-4) + 5-nitro-1,3-benzenedicarbonylchloride (13438-30-7) → bis[8-[(tetrahydro-2H-pyran-2-yl)oxy]octyl] 5-nitroisophthalate (406206-21-1)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 0 ℃; for 2h;

DOI:10.1021/jo0160930

Reference yield:

bis[8-[(tetrahydro-2H-pyran-2-yl)oxy]octyl] 5-nitroisophthalate (406206-21-1) → 5-amino-isophthalic acid bis-[8-(tetrahydro-pyran-2-yloxy)-octyl] ester

Guidance literature:

With hydrogenchloride; hydrogen; platinum(IV) oxide; In ethanol; for 2h; under 1292.9 Torr;

DOI:10.1021/jo0160930

Reference yield:

bis[8-[(tetrahydro-2H-pyran-2-yl)oxy]octyl] 5-nitroisophthalate (406206-21-1) → bis(8-hydroxyoctyl) N-tert-butoxycarbonyl-5-aminoisophthalate (406206-23-3)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogen; HCl / PtO₂ / aq. ethanol / 2 h / 1292.9 Torr

2: tetrahydrofuran / 16 h / 20 °C

3: 70 percent / aq. HCl / methanol / 1 h / 20 °C

With hydrogenchloride; hydrogen; platinum(IV) oxide; In tetrahydrofuran; methanol; ethanol;

DOI:10.1021/jo0160930

upstream raw materials:

8-(tetrahydro-2H-pyran-2-yloxy)octan-1-ol

5-nitro-1,3-benzenedicarbonylchloride

Downstream raw materials:

bis(8-hydroxyoctyl) N-tert-butoxycarbonyl-5-aminoisophthalate

bis[8-[(tetrahydro-2H-pyran-2-yl)oxy]octyl] N-tert-butoxycarbonyl-5-aminoisophthalate