Technology Process of 2-(2,2-diethyl-4-methyl-[1,3]dioxolan-4-yl)-5-(4-methoxy-benzyloxymethyl)-hex-5-enal
There total 11 articles about 2-(2,2-diethyl-4-methyl-[1,3]dioxolan-4-yl)-5-(4-methoxy-benzyloxymethyl)-hex-5-enal which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
dipyridinium dichromate; 4 A molecular sieve;
In
dichloromethane;
at 20 ℃;
for 6h;
DOI:10.1002/anie.200602056
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 97 percent / DCC; DMAP / CH2Cl2 / 3.08 h / 0 - 20 °C
2: diisopropylamine; n-BuLi / tetrahydrofuran; hexane / 2 h / -78 - 20 °C
3: [Cu{(S,S)-t-Bu-box)}](OTf)2; 4 Angstroem molecular sieves / CH2Cl2 / 15 h / -78 °C
4: 2,6-lutidine / CH2Cl2 / 0.5 h / 20 °C
5: LiAlH4 / tetrahydrofuran / 3 h / 0 °C
6: TBAF / tetrahydrofuran / 2 h / 20 °C
7: TsOH*H2O / 1 h / 20 °C
8: PDC; 4 Angstroem molecular sieves / CH2Cl2 / 6 h / 20 °C
With
2,6-dimethylpyridine; dmap; lithium aluminium tetrahydride; dipyridinium dichromate; n-butyllithium; [Cu(2,2-bis(4(S)-t-Bu-oxazolidin-2-yl)propane)](OTf)2; 4 A molecular sieve; tetrabutyl ammonium fluoride; toluene-4-sulfonic acid; diisopropylamine; dicyclohexyl-carbodiimide;
In
tetrahydrofuran; hexane; dichloromethane;
3: Evans aldol reaction;
DOI:10.1002/anie.200602056
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 96 percent / aq. NaOH / methanol / 4 h / 20 °C
2: 97 percent / DCC; DMAP / CH2Cl2 / 3.08 h / 0 - 20 °C
3: diisopropylamine; n-BuLi / tetrahydrofuran; hexane / 2 h / -78 - 20 °C
4: [Cu{(S,S)-t-Bu-box)}](OTf)2; 4 Angstroem molecular sieves / CH2Cl2 / 15 h / -78 °C
5: 2,6-lutidine / CH2Cl2 / 0.5 h / 20 °C
6: LiAlH4 / tetrahydrofuran / 3 h / 0 °C
7: TBAF / tetrahydrofuran / 2 h / 20 °C
8: TsOH*H2O / 1 h / 20 °C
9: PDC; 4 Angstroem molecular sieves / CH2Cl2 / 6 h / 20 °C
With
2,6-dimethylpyridine; dmap; sodium hydroxide; lithium aluminium tetrahydride; dipyridinium dichromate; n-butyllithium; [Cu(2,2-bis(4(S)-t-Bu-oxazolidin-2-yl)propane)](OTf)2; 4 A molecular sieve; tetrabutyl ammonium fluoride; toluene-4-sulfonic acid; diisopropylamine; dicyclohexyl-carbodiimide;
In
tetrahydrofuran; methanol; hexane; dichloromethane;
4: Evans aldol reaction;
DOI:10.1002/anie.200602056
![2-(2,2-diethyl-4-methyl-[1,3]dioxolan-4-yl)-5-(4-methoxy-benzyloxymethyl)-hex-5-en-1-ol](/Databaselist/images/loading.webp)
