Technology Process of ethyl (2-amino-5-fluoro-4-((4-fluorobenzyl)amino)phenyl)carbamate
There total 3 articles about ethyl (2-amino-5-fluoro-4-((4-fluorobenzyl)amino)phenyl)carbamate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
6-fluoro-N1-(4-fluorobenzyl)-4-nitrobenzene-1,3-diamine;
With
ammonium chloride; zinc;
In
methanol;
at 20 ℃;
for 5h;
chloroformic acid ethyl ester;
With
N-ethyl-N,N-diisopropylamine;
In
methanol;
at 0 - 20 ℃;
for 3h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: ammonia / methanol / 1.5 h / 70 °C / Microwave irradiation
2.1: triethylamine; iodine / dimethyl sulfoxide / 16 h / 120 °C
3.1: ammonium chloride; zinc / methanol / 5 h / 20 °C
3.2: 3 h / 0 - 20 °C
With
ammonia; iodine; ammonium chloride; triethylamine; zinc;
In
methanol; dimethyl sulfoxide;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: triethylamine; iodine / dimethyl sulfoxide / 16 h / 120 °C
2.1: ammonium chloride; zinc / methanol / 5 h / 20 °C
2.2: 3 h / 0 - 20 °C
With
iodine; ammonium chloride; triethylamine; zinc;
In
methanol; dimethyl sulfoxide;