Technology Process of (4R,5S,6S,7R)-hexahydro-5,6-isopropylidenedioxy-4,7-bis(phenylmethyl)-2H-diazapin-2-one
There total 10 articles about (4R,5S,6S,7R)-hexahydro-5,6-isopropylidenedioxy-4,7-bis(phenylmethyl)-2H-diazapin-2-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
4-methyl-morpholine;
In
toluene;
at 100 ℃;
for 1h;
DOI:10.1021/jo980980u
- Guidance literature:
-
Multi-step reaction with 7 steps
1: H2 / Pd(OH)2 / ethyl acetate / 24 h / 760 Torr / Ambient temperature
2: 1.) (COCl)2, DMSO, 2.) DIPEA / 1.) CH2Cl2, -78 deg C, 1 h, 2.) CH2Cl2, -78 deg C to 0 deg C
3: MgSO4 / CH2Cl2 / 4 h / Ambient temperature
4: 74 percent / tetrahydrofuran; diethyl ether / 3 h / -78 °C
5: Cu(OAc)2*H2O, Zn / acetic acid; H2O / 4 h / Ambient temperature
6: NaBH4 / ethanol / 18 h / 60 °C
7: 77 percent / N-methylmorpholine / toluene / 1 h / 100 °C
With
4-methyl-morpholine; sodium tetrahydroborate; copper diacetate; oxalyl dichloride; hydrogen; magnesium sulfate; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; zinc;
palladium dihydroxide;
In
tetrahydrofuran; diethyl ether; ethanol; dichloromethane; water; acetic acid; ethyl acetate; toluene;
DOI:10.1021/jo980980u
- Guidance literature:
-
Multi-step reaction with 5 steps
1: MgSO4 / CH2Cl2 / 4 h / Ambient temperature
2: 74 percent / tetrahydrofuran; diethyl ether / 3 h / -78 °C
3: Cu(OAc)2*H2O, Zn / acetic acid; H2O / 4 h / Ambient temperature
4: NaBH4 / ethanol / 18 h / 60 °C
5: 77 percent / N-methylmorpholine / toluene / 1 h / 100 °C
With
4-methyl-morpholine; sodium tetrahydroborate; copper diacetate; magnesium sulfate; zinc;
In
tetrahydrofuran; diethyl ether; ethanol; dichloromethane; water; acetic acid; toluene;
DOI:10.1021/jo980980u
