Toluene-4-sulfonic acid (S)-1-[2-(3,5-dimethoxy-phenyl)-ethyl]-3-methyl-pentyl ester

Base Information

Chemical Name:Toluene-4-sulfonic acid (S)-1-[2-(3,5-dimethoxy-phenyl)-ethyl]-3-methyl-pentyl ester
CAS No.:220170-13-8
Molecular Formula:C₂₃H₃₂O₅S
Molecular Weight:420.57
Hs Code.:

Synonyms:Toluene-4-sulfonic acid (S)-1-[2-(3,5-dimethoxy-phenyl)-ethyl]-3-methyl-pentyl ester

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Chemical Property of Toluene-4-sulfonic acid (S)-1-[2-(3,5-dimethoxy-phenyl)-ethyl]-3-methyl-pentyl ester

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Technology Process of Toluene-4-sulfonic acid (S)-1-[2-(3,5-dimethoxy-phenyl)-ethyl]-3-methyl-pentyl ester

There total 3 articles about Toluene-4-sulfonic acid (S)-1-[2-(3,5-dimethoxy-phenyl)-ethyl]-3-methyl-pentyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 98-59-9
p-toluenesulfonyl chloride

: 220169-88-0
(S)-1-(3,5-Dimethoxy-phenyl)-5-methyl-heptan-3-ol

: 220170-13-8
Toluene-4-sulfonic acid (S)-1-[2-(3,5-dimethoxy-phenyl)-ethyl]-3-methyl-pentyl ester

Guidance literature:: With pyridine; In chloroform; at 0 - 20 ℃; for 3h;
DOI:10.1016/S0968-0896(98)80014-X

Reference yield:

: 1080-05-3
3-(3,5-dimethoxyphenyl)-1-propanol

: 220170-13-8
Toluene-4-sulfonic acid (S)-1-[2-(3,5-dimethoxy-phenyl)-ethyl]-3-methyl-pentyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 96 percent / oxalyl chloride; DMSO; triethylamine / CH₂Cl₂ / 2.3 h / -60 - 20 °C

2.1: Mg; p-toluenesulfonic acid monohydrate; 1,2-dibromoethane / diethyl ether / 2.5 h / Heating

2.2: 56 percent / diethyl ether / 2.25 h / Heating

3.1: 79 percent / pyridine / CHCl₃ / 3 h / 0 - 20 °C

With pyridine; oxalyl dichloride; toluene-4-sulfonic acid; magnesium; dimethyl sulfoxide; ethylene dibromide; triethylamine; In diethyl ether; dichloromethane; chloroform; 1.1: Oxidation / 2.1: Metallation / 2.2: Grignard reaction / 3.1: Tosylation;
DOI:10.1016/S0968-0896(98)80014-X

Reference yield:

: 125187-47-5
3-(3,5-dimethoxyphenyl)-1-propanal

: 220170-13-8
Toluene-4-sulfonic acid (S)-1-[2-(3,5-dimethoxy-phenyl)-ethyl]-3-methyl-pentyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: Mg; p-toluenesulfonic acid monohydrate; 1,2-dibromoethane / diethyl ether / 2.5 h / Heating

1.2: 56 percent / diethyl ether / 2.25 h / Heating

2.1: 79 percent / pyridine / CHCl₃ / 3 h / 0 - 20 °C

With pyridine; toluene-4-sulfonic acid; magnesium; ethylene dibromide; In diethyl ether; chloroform; 1.1: Metallation / 1.2: Grignard reaction / 2.1: Tosylation;
DOI:10.1016/S0968-0896(98)80014-X