2'-((E)-Styryl)-[2,4']bioxazolyl-4-carboxylic acid ethyl ester

Base Information

• Chemical Name: 2'-((E)-Styryl)-[2,4']bioxazolyl-4-carboxylic acid ethyl ester
• CAS No.: 194232-58-1
• Molecular Formula: C₁₇H₁₄N₂O₄
• Molecular Weight: 310.309
• Mol file: 194232-58-1.mol

Synonyms:2'-((E)-Styryl)-[2,4']bioxazolyl-4-carboxylic acid ethyl ester

Chemical Property of 2'-((E)-Styryl)-[2,4']bioxazolyl-4-carboxylic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2'-((E)-Styryl)-[2,4']bioxazolyl-4-carboxylic acid ethyl ester

There total 2 articles about 2'-((E)-Styryl)-[2,4']bioxazolyl-4-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

cinnamamide (621-79-4,22031-64-7) → 2'-((E)-Styryl)-[2,4']bioxazolyl-4-carboxylic acid ethyl ester (194232-58-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) NaHCO₃; 2.) TFAA / 1.) THF; 2.) THF

2: 100 percent / aq. NH₄OH / Ambient temperature

3: 1.) NaHCO₃; 2.) TFAA / 1.) THF; 2.) THF

With ammonium hydroxide; sodium hydrogencarbonate; trifluoroacetic anhydride;

DOI:10.1016/S0040-4039(97)01218-5

Reference yield:

ethyl Bromopyruvate (70-23-5) + 2-((E)-Styryl)-oxazole-4-carboxylic acid amide (194232-57-0) → 2'-((E)-Styryl)-[2,4']bioxazolyl-4-carboxylic acid ethyl ester (194232-58-1)

Guidance literature:

With sodium hydrogencarbonate; trifluoroacetic anhydride; Yield given. Multistep reaction; 1.) THF; 2.) THF;

DOI:10.1016/S0040-4039(97)01218-5

Reference yield:

2'-((E)-Styryl)-[2,4']bioxazolyl-4-carboxylic acid ethyl ester (194232-58-1) → 2'-(tert-Butyl-diphenyl-silanyloxymethyl)-[2,4']bioxazolyl-4-carboxylic acid amide (194232-60-5)

Guidance literature:

Multi-step reaction with 5 steps

1: TNANO / OsO₄

2: Pb(OAc)4

3: NaBH₄ / ethanol / 0 °C

4: NH₄OH

5: imidazole

With 1H-imidazole; lead(IV) acetate; ammonium hydroxide; sodium tetrahydroborate; osmium(VIII) oxide; In ethanol;

DOI:10.1016/S0040-4039(97)01218-5

upstream raw materials:

ethyl Bromopyruvate

2-((E)-Styryl)-oxazole-4-carboxylic acid amide

cinnamamide

Downstream raw materials:

2'-(tert-Butyl-diphenyl-silanyloxymethyl)-[2,4']bioxazolyl-4-carboxylic acid amide

2''-(tert-Butyl-diphenyl-silanyloxymethyl)-[2,4';2',4'']teroxazole-4-carbaldehyde

2''-(tert-Butyl-diphenyl-silanyloxymethyl)-[2,4';2',4'']teroxazole-4-carboxylic acid ethyl ester