5?(2?chloroacetyl)?2?thioxo?1,3?di?p?tolyldihydropyrimidine?4,6(1H,5H)?dione

Base Information

• Chemical Name: 5?(2?chloroacetyl)?2?thioxo?1,3?di?p?tolyldihydropyrimidine?4,6(1H,5H)?dione
• CAS No.: 135764-08-8
• Molecular Formula: C₂₀H₁₇ClN₂O₃S
• Molecular Weight: 400.886

Synonyms:5?(2?chloroacetyl)?2?thioxo?1,3?di?p?tolyldihydropyrimidine?4,6(1H,5H)?dione

Chemical Property of 5?(2?chloroacetyl)?2?thioxo?1,3?di?p?tolyldihydropyrimidine?4,6(1H,5H)?dione

Chemical Property:

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Technology Process of 5?(2?chloroacetyl)?2?thioxo?1,3?di?p?tolyldihydropyrimidine?4,6(1H,5H)?dione

There total 3 articles about 5?(2?chloroacetyl)?2?thioxo?1,3?di?p?tolyldihydropyrimidine?4,6(1H,5H)?dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.7%

1,3-di(4-methylphenyl)-2-thiobarbituric acid (55138-39-1) + chloroacetyl chloride (79-04-9) → 5?(2?chloroacetyl)?2?thioxo?1,3?di?p?tolyldihydropyrimidine?4,6(1H,5H)?dione (135764-08-8)

Guidance literature:

With triethylamine; In benzene; for 0.5h; Heating;

Reference yield:

p-toluidine (106-49-0,12221-03-3) → 5?(2?chloroacetyl)?2?thioxo?1,3?di?p?tolyldihydropyrimidine?4,6(1H,5H)?dione (135764-08-8)

Guidance literature:

Multi-step reaction with 3 steps

1: ethanol / Reflux

2: acetyl chloride / 40 - 50 °C

3: N,N-dimethyl-formamide / 20 °C

With acetyl chloride; In ethanol; N,N-dimethyl-formamide;

DOI:10.1007/s13738-021-02448-w

Reference yield:

N,N'-Bis(p-tolyl)thiourea (621-01-2) → 5?(2?chloroacetyl)?2?thioxo?1,3?di?p?tolyldihydropyrimidine?4,6(1H,5H)?dione (135764-08-8)

Guidance literature:

Multi-step reaction with 2 steps

1: acetyl chloride / 40 - 50 °C

2: N,N-dimethyl-formamide / 20 °C

With acetyl chloride; In N,N-dimethyl-formamide;

DOI:10.1007/s13738-021-02448-w

upstream raw materials:

1,3-di(4-methylphenyl)-2-thiobarbituric acid

chloroacetyl chloride

p-toluidine

N,N'-Bis(p-tolyl)thiourea

Downstream raw materials:

2-Thioxo-1,3-di-p-tolyl-2,3-dihydro-1H-furo[2,3-d]pyrimidine-4,5-dione

5-(2-Methyl-thiazol-4-yl)-2-thioxo-1,3-di-p-tolyl-dihydro-pyrimidine-4,6-dione

2-hydrazino-4-[1,3-bis(4-methylphenyl)-4,6-dioxo-2-thioxohexahydropyrimidin-5-yl]thiazole

5-(2-Amino-thiazol-4-yl)-2-thioxo-1,3-di-p-tolyl-dihydro-pyrimidine-4,6-dione

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