(1'R,1R)-2-{1-[3'-benzyloxy-1'-(4-methoxybenzyloxy)propyl]but-3-enyloxy}-N,N-dimethylacetamide

Base Information

Chemical Name:(1'R,1R)-2-{1-[3'-benzyloxy-1'-(4-methoxybenzyloxy)propyl]but-3-enyloxy}-N,N-dimethylacetamide
CAS No.:869385-99-9
Molecular Formula:C₂₆H₃₅NO₅
Molecular Weight:441.568
Hs Code.:

Synonyms:(1'R,1R)-2-{1-[3'-benzyloxy-1'-(4-methoxybenzyloxy)propyl]but-3-enyloxy}-N,N-dimethylacetamide

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Chemical Property of (1'R,1R)-2-{1-[3'-benzyloxy-1'-(4-methoxybenzyloxy)propyl]but-3-enyloxy}-N,N-dimethylacetamide

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Technology Process of (1'R,1R)-2-{1-[3'-benzyloxy-1'-(4-methoxybenzyloxy)propyl]but-3-enyloxy}-N,N-dimethylacetamide

There total 2 articles about (1'R,1R)-2-{1-[3'-benzyloxy-1'-(4-methoxybenzyloxy)propyl]but-3-enyloxy}-N,N-dimethylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 869386-01-6
(4R,5R)-7-benzyloxy-5-(4-methoxybenzyloxy)hept-1-en-4-ol

: 2675-89-0
2-chloro-N,N-dimethylacetamide

: 869385-99-9
(1'R,1R)-2-{1-[3'-benzyloxy-1'-(4-methoxybenzyloxy)propyl]but-3-enyloxy}-N,N-dimethylacetamide

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 20 ℃; for 3h;
DOI:10.1021/jo050974f

Reference yield:

: (R)-2-[(R)-3-Benzyloxy-1-(4-methoxy-benzyloxy)-propyl]-oxirane

: 869385-99-9
(1'R,1R)-2-{1-[3'-benzyloxy-1'-(4-methoxybenzyloxy)propyl]but-3-enyloxy}-N,N-dimethylacetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: CuI / tetrahydrofuran / 0.25 h / -30 °C

1.2: 90 percent / tetrahydrofuran / 0.25 h / -30 °C

2.1: 95 percent / NaH / tetrahydrofuran / 3 h / 20 °C

With copper(l) iodide; sodium hydride; In tetrahydrofuran;
DOI:10.1021/jo050974f

Reference yield:

: 869385-99-9
(1'R,1R)-2-{1-[3'-benzyloxy-1'-(4-methoxybenzyloxy)propyl]but-3-enyloxy}-N,N-dimethylacetamide

: 106-95-6
allyl bromide

: (1'R,1''R,2R)-2-{1''-[3'-benzyloxy-1'-(4-methoxybenzyloxy)propyl]but-3''-enyloxy}pent-4-enoic acid dimethylamide

: (S)-2-{(R)-1-[(R)-3-Benzyloxy-1-(4-methoxy-benzyloxy)-propyl]-but-3-enyloxy}-pent-4-enoic acid dimethylamide

Guidance literature:: (1'R,1R)-2-{1-[3'-benzyloxy-1'-(4-methoxybenzyloxy)propyl]but-3-enyloxy}-N,N-dimethylacetamide; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.333333h;

allyl bromide; In tetrahydrofuran; at -78 ℃; for 0.166667h; Title compound not separated from byproducts;
DOI:10.1021/jo050974f