(p-Carboxyphenyl)-propiolsaeure

Base Information

• Chemical Name: (p-Carboxyphenyl)-propiolsaeure
• CAS No.: 10602-02-5
• Molecular Formula: C₁₀H₆O₄
• Molecular Weight: 190.155
• Mol file: 10602-02-5.mol

Synonyms:(p-Carboxyphenyl)-propiolsaeure

Chemical Property of (p-Carboxyphenyl)-propiolsaeure

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (p-Carboxyphenyl)-propiolsaeure

There total 7 articles about (p-Carboxyphenyl)-propiolsaeure which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-iodobenzoic acid (619-58-9) + Propiolic acid (471-25-0) → (p-Carboxyphenyl)-propiolsaeure (10602-02-5)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 5h; Inert atmosphere;

DOI:10.1016/j.tetlet.2012.06.023

Reference yield:

4-(1,2-Dibromo-2-ethoxycarbonyl-ethyl)-benzoic acid ethyl ester → (p-Carboxyphenyl)-propiolsaeure (10602-02-5)

Guidance literature:

With potassium hydroxide; In ethanol; for 24h; Heating;

DOI:10.1021/jo01346a032

Reference yield:

p-bromobenzaldehyde 1,3-dioxolane (10602-01-4) → (p-Carboxyphenyl)-propiolsaeure (10602-02-5)

Guidance literature:

Multi-step reaction with 5 steps

1: (i) Mg, THF, (ii) /BRN= 1900390/, (iii) aq. H₂SO₄

2: NaOAc / 10 h / 150 - 160 °C / Heating

3: (i) SOCl₂, (ii) /BRN= 1718733/

4: Br₂ / CHCl₃ / 10 h / Heating

5: KOH / ethanol / 24 h / Heating

With potassium hydroxide; bromine; sodium acetate; In ethanol; chloroform;

DOI:10.1021/jo01346a032

upstream raw materials:

4-bromo-1-ethynylbenzene

carbon dioxide

p-bromobenzaldehyde 1,3-dioxolane

4-ethoxycarbonyl-cinnamic acid ethyl ester

Downstream raw materials:

4-Ethynyl-benzoic acid

2-(4-carboxy-phenyl)-aza-indene