Technology Process of dibenzyl-N-benzyloxycarbonylglycyl-L-pyroglutamyl-L-glutamate
There total 4 articles about dibenzyl-N-benzyloxycarbonylglycyl-L-pyroglutamyl-L-glutamate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
tert-butyl-N-benzyloxycarbonylglycyl-L-pyroglutamic acid; L-glutamic acid dibenzyl ester 4-toluenesulfonate;
With
bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride;
In
dichloromethane;
at 0 ℃;
With
triethylamine;
In
dichloromethane;
at 0 ℃;
for 0.0833333h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.33 h / -78 °C
2.1: trifluoroacetic acid / dichloromethane / 1.5 h / 0 °C
3.1: bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride / dichloromethane / 0 °C
3.2: 0.08 h / 0 °C
With
bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; trifluoroacetic acid; lithium hexamethyldisilazane;
In
tetrahydrofuran; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: dicyclohexyl-carbodiimide / 1,2-dimethoxyethane / 21.5 h / -5 °C
2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.33 h / -78 °C
3.1: trifluoroacetic acid / dichloromethane / 1.5 h / 0 °C
4.1: bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride / dichloromethane / 0 °C
4.2: 0.08 h / 0 °C
With
bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; dicyclohexyl-carbodiimide; trifluoroacetic acid; lithium hexamethyldisilazane;
In
tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane;
