(3S,6S)-1-(2-Azido-benzoyl)-4-(2,4-dimethoxy-benzyl)-3-methyl-6-[1-(2,2,2-trifluoro-acetyl)-2,3-dihydro-1H-indol-3-ylmethyl]-piperazine-2,5-dione

Base Information

Chemical Name:(3S,6S)-1-(2-Azido-benzoyl)-4-(2,4-dimethoxy-benzyl)-3-methyl-6-[1-(2,2,2-trifluoro-acetyl)-2,3-dihydro-1H-indol-3-ylmethyl]-piperazine-2,5-dione
CAS No.:191474-60-9
Molecular Formula:C₃₂H₂₉F₃N₆O₆
Molecular Weight:650.614
Hs Code.:

Synonyms:(3S,6S)-1-(2-Azido-benzoyl)-4-(2,4-dimethoxy-benzyl)-3-methyl-6-[1-(2,2,2-trifluoro-acetyl)-2,3-dihydro-1H-indol-3-ylmethyl]-piperazine-2,5-dione

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Chemical Property of (3S,6S)-1-(2-Azido-benzoyl)-4-(2,4-dimethoxy-benzyl)-3-methyl-6-[1-(2,2,2-trifluoro-acetyl)-2,3-dihydro-1H-indol-3-ylmethyl]-piperazine-2,5-dione

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Technology Process of (3S,6S)-1-(2-Azido-benzoyl)-4-(2,4-dimethoxy-benzyl)-3-methyl-6-[1-(2,2,2-trifluoro-acetyl)-2,3-dihydro-1H-indol-3-ylmethyl]-piperazine-2,5-dione

There total 8 articles about (3S,6S)-1-(2-Azido-benzoyl)-4-(2,4-dimethoxy-benzyl)-3-methyl-6-[1-(2,2,2-trifluoro-acetyl)-2,3-dihydro-1H-indol-3-ylmethyl]-piperazine-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 34897-85-3
o-azidobenzoyl chloride

: 191474-59-6
(3S,6S)-1-(2,4-Dimethoxy-benzyl)-6-methyl-3-[1-(2,2,2-trifluoro-acetyl)-2,3-dihydro-1H-indol-3-ylmethyl]-piperazine-2,5-dione

: 191474-60-9
(3S,6S)-1-(2-Azido-benzoyl)-4-(2,4-dimethoxy-benzyl)-3-methyl-6-[1-(2,2,2-trifluoro-acetyl)-2,3-dihydro-1H-indol-3-ylmethyl]-piperazine-2,5-dione

Guidance literature:: DOI:10.1055/s-1997-6137

Reference yield:

: 20781-20-8
2,4-Dimethoxybenzylamine

: 191474-60-9
(3S,6S)-1-(2-Azido-benzoyl)-4-(2,4-dimethoxy-benzyl)-3-methyl-6-[1-(2,2,2-trifluoro-acetyl)-2,3-dihydro-1H-indol-3-ylmethyl]-piperazine-2,5-dione

Guidance literature:: Multi-step reaction with 8 steps

1: 100 percent / DCC

2: 83 percent / BH₃, TFA / tetrahydrofuran

3: 97 percent / Et₃N

4: 100 percent / H₂ / Pd/C

5: 63 percent

6: 89 percent / TFA / toluene / Heating

7: 100 percent / H₂ / Pd/C

8: 85 percent

With borane; hydrogen; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; toluene;
DOI:10.1055/s-1997-6137

Reference yield:

: 191474-56-3
(S)-2-Amino-N-(2,4-dimethoxy-benzyl)-3-[1-(2,2,2-trifluoro-acetyl)-2,3-dihydro-1H-indol-3-yl]-propionamide

: 191474-60-9
(3S,6S)-1-(2-Azido-benzoyl)-4-(2,4-dimethoxy-benzyl)-3-methyl-6-[1-(2,2,2-trifluoro-acetyl)-2,3-dihydro-1H-indol-3-ylmethyl]-piperazine-2,5-dione

Guidance literature:: Multi-step reaction with 4 steps

1: 63 percent

2: 89 percent / TFA / toluene / Heating

3: 100 percent / H₂ / Pd/C

4: 85 percent

With hydrogen; trifluoroacetic acid; palladium on activated charcoal; In toluene;
DOI:10.1055/s-1997-6137